خانه
تصادفی
در نزدیکی
ورود
تنظیمات
کمک مالی
دربارهٔ ویکیپدیا
تکذیبنامهها
جستجو
الگو
:
PBB/101
زبان
پیگیری
ویرایش
<
الگو:PBB
ADAM metallopeptidase domain 8
ساختارهای موجود
بانک داده پروتئین
Ortholog search:
PDBe
,
RCSB
فهرست کدهای شناسه PDB
4DD8
شاخصها
نماد ژن
ADAM8
; CD156; MS2
شناسههای بیرونی
OMIM
:
602267
MGI
:
107825
HomoloGene
:
74384
GeneCards
:
ADAM8 Gene
EC number
3.4.24.-
هستیشناسی ژن
Molecular function
•
metalloendopeptidase activity
•
calcium ion binding
•
protein binding
•
metallopeptidase activity
•
zinc ion binding
•
protein self-association
•
cell adhesion molecule binding
Cellular component
•
podosome
•
cytoplasm
•
plasma membrane
•
integral to plasma membrane
•
cell surface
•
phagolysosome
•
dense core granule membrane
•
specific granule
•
tertiary granule
•
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
•
alpha9-beta1 integrin-ADAM8 complex
Biological process
•
cell morphogenesis
•
angiogenesis
•
leukocyte migration involved in inflammatory response
•
positive regulation of acute inflammatory response
•
proteolysis
•
inflammatory response
•
positive regulation of protein processing
•
regulation of cell-cell adhesion
•
positive regulation of T cell differentiation in thymus
•
activation of MAPK activity involved in innate immune response
•
negative regulation of neuron apoptotic process
•
positive regulation of bone resorption
•
positive regulation of cell adhesion
•
lymphocyte chemotaxis
•
positive regulation of protein secretion
•
positive regulation of membrane protein ectodomain proteolysis
•
positive regulation of NF-kappaB transcription factor activity
•
positive regulation of protein kinase B signaling cascade
•
positive regulation of thymocyte apoptotic process
•
cellular response to hypoxia
•
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
•
positive regulation of neutrophil extravasation
•
positive regulation of fibronectin-dependent thymocyte migration
•
positive regulation of eosinophil migration
Sources:
Amigo
/
QuickGO
الگوی بیان RNA
دادهای بیان مرجع بیشتر
اورتولوگ
گونهها
انسان
موش
آنتره
101
11501
آنسامبل
ENSG00000151651
ENSMUSG00000025473
UniProt
P78325
Q05910
RefSeq (mRNA)
NM_001109.4
NM_007403.2
RefSeq (protein)
NP_001100.3
NP_031429.1
موقعیت (UCSC)
Chr 10:
135.08 – 135.09 Mb
Chr 7:
139.98 – 139.99 Mb
جستجوی
پابمد
[۱]
[۲]
ن
ب
و