بکلین ۱

BECN1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: K7ER46 PDBe K7ER46 RCSB
فهرست شناسه‌های PDB
	2P1L, 2PON, 3DVU, 4DDP, 4MI8
معین‌کننده‌ها
نام‌های دیگر	BECN1, ATG6, VPS30, beclin1, beclin 1
شناسه‌های بیرونی	OMIM: 604378 MGI: 1891828 HomoloGene: 2794 GeneCards: BECN1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	101,193,112 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• phosphatidylinositol 3-kinase binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • GTPase binding; • ubiquitin protein ligase binding; • protein kinase binding; • protein homodimerization activity;
ترکیبات سلولی	• endosome membrane; • سیتوپلاسم; • mitochondrial membranes; • trans-Golgi network; • دستگاه گلژی; • سیتوزول; • هسته یاخته; • autophagosome; • phagophore assembly site; • membrane; • دندریت; • شبکه آندوپلاسمی; • phosphatidylinositol 3-kinase complex, class III; • endoplasmic reticulum membrane; • phosphatidylinositol 3-kinase complex, class III, type II; • GO:0016023 cytoplasmic vesicle; • اندوزوم; • extrinsic component of membrane; • phosphatidylinositol 3-kinase complex, class III, type I; • phagocytic vesicle; • میتوکندری; • GO:0009327 protein-containing complex;
فرایند زیستی	• negative regulation of cell population proliferation; • response to hypoxia; • cellular response to aluminum ion; • response to vitamin E; • lysosome organization; • چرخه یاخته‌ای; • positive regulation of phosphatidylinositol 3-kinase signaling; • cellular response to glucose starvation; • cellular defense response; • تقسیم درون‌یاخته; • cellular response to epidermal growth factor stimulus; • تقسیم یاخته; • receptor catabolic process; • autophagy of nucleus; • cellular response to nitrogen starvation; • GO:0022415 viral process; • late endosome to vacuole transport; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • cytoplasm to vacuole transport by the Cvt pathway; • اندوسیتوز; • engulfment of apoptotic cell; • positive regulation of attachment of mitotic spindle microtubules to kinetochore; • amyloid-beta metabolic process; • neuron development; • defense response to virus; • response to other organism; • mitotic metaphase plate congression; • GO:0048552 regulation of catalytic activity; • negative regulation of reactive oxygen species metabolic process; • regulation of cytokinesis; • negative regulation of apoptotic process; • negative regulation of cell death; • autophagosome assembly; • macroautophagy; • GO:0010260 پیرش; • response to iron(II) ion; • response to lead ion; • protein deubiquitination; • response to nutrient levels; • cellular response to amino acid starvation; • cellular response to hydrogen peroxide; • cellular response to copper ion; • negative regulation of lysosome organization; • positive regulation of autophagosome assembly; • میتوفاژی; • mitophagy; • خودخواری; • positive regulation of autophagy; • response to mitochondrial depolarisation; • early endosome to late endosome transport; • negative regulation of autophagy; • positive regulation of cardiac muscle hypertrophy; • negative regulation of autophagosome assembly; • positive regulation of intrinsic apoptotic signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8678
	56208
	ENSG00000126581
	ENSMUSG00000035086
	K7ER46 Q14457، K7ER46
	O88597
	NM_001313999، NM_001314000، NM_003766، XM_005257759، XM_005257760، XM_017025263، XM_017025264 NM_001313998، NM_001313999، NM_001314000، NM_003766، XM_005257759، XM_005257760، XM_017025263، XM_017025264
	NM_001359819، NM_001359820، NM_001359821 NM_019584، NM_001359819، NM_001359820، NM_001359821
	NP_001300928، NP_001300929، NP_003757، XP_005257816، XP_005257817، XP_011523723، XP_016880751، XP_016880752، XP_016880753 NP_001300927، NP_001300928، NP_001300929، NP_003757، XP_005257816، XP_005257817، XP_011523723، XP_016880751، XP_016880752، XP_016880753
	NP_001346748، NP_001346749، NP_001346750 NP_062530، NP_001346748، NP_001346749، NP_001346750
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

بکلین ۱ (انگلیسی: Beclin-1) یک پروتئین است که در انسان توسط ژن «BECN1» کُدگذاری می‌شود.^[۴]^[۵] این پروتئین با Bcl-2 و «PI-3K نوع ۳» تعامل پروتئین-پروتئین دارد و نقش بسیار مهمی در تنظیم خودخواری و مرگ یاخته ایفا می‌کند.

اهمیت بالینی ویرایش

بکلین ۱ از طریق دخالت در خودخواری و مرگ یاخته، نقش مهمی در سرطان‌زایی و زوال عصبی انسان بازی می‌کند.^[۶] در سرطان‌های تخمدانی که این میزان خودخواری بالاست، ماهیت تهاجمی کمتری دارد و پاسخ بهتری به شیمی‌درمانی می‌دهند.^[۷]

بروز اسکیزوفرنی با سطح کم بکلین ۱ در هیپوکامپ مرتبط است که سبب کاهش خودخواری و افزایش مرگ سلول‌های عصبی می‌گردد.^[۸]

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000035086 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al. (November 1998). "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein". Journal of Virology. 72 (11): 8586–96. doi:10.1128/JVI.72.11.8586-8596.1998. PMC 110269. PMID 9765397.
↑ "Entrez Gene: BECN1 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)".
↑ Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, et al. (April 2009). "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex". Nature Cell Biology. 11 (4): 468–76. doi:10.1038/ncb1854. PMC 2664389. PMID 19270693.
↑ Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, et al. (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". BioMed Research International. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242. PMID 25136588.
↑ Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, et al. (February 2015). "Autophagy has a key role in the pathophysiology of schizophrenia". Molecular Psychiatry. 20 (1): 126–32. doi:10.1038/mp.2013.174. PMC 4320293. PMID 24365867.*Lay summary in: Whiteman H (January 1, 2014). "New molecular discovery provides clues to cause of schizophrenia". MediLexicon International Ltd.

مشارکت‌کنندگان ویکی‌پدیا. «BECN1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر ویرایش

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پیوند به بیرون ویرایش

مکان ژنوم BECN1 انسانی و صفحهٔ جزئیات ژنی BECN1 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: Q14457 (Beclin-1) در PDBe-KB.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000035086 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9765397-4] Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al. (November 1998). "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein". Journal of Virology. 72 (11): 8586–96. doi:10.1128/JVI.72.11.8586-8596.1998. PMC 110269. PMID 9765397.

[entrez-5] "Entrez Gene: BECN1 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)".

[pmid19270693-6] Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, et al. (April 2009). "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex". Nature Cell Biology. 11 (4): 468–76. doi:10.1038/ncb1854. PMC 2664389. PMID 19270693.

[Valente_2014-7] Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, et al. (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". BioMed Research International. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242. PMID 25136588.

[pmid24365867-8] Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, et al. (February 2015). "Autophagy has a key role in the pathophysiology of schizophrenia". Molecular Psychiatry. 20 (1): 126–32. doi:10.1038/mp.2013.174. PMC 4320293. PMID 24365867.*Lay summary in: Whiteman H (January 1, 2014). "New molecular discovery provides clues to cause of schizophrenia". MediLexicon International Ltd.

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