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خلاصه

The gp120 envelope glycoprotein binds sequentially to the cellular receptors CD4 and a member of the chemokine receptor family (CXCR4 or CCR5) to initiate virus cell entry; Kwong et al., Nature, 420, 678-682 (12 December 2002). The antibody-protein binding to the CD4 receptor attempts to block the chemokine-receptor binding, thus prevent HIV-1 virus cell entry. Both gp120 and CD4 are glycoproteins Kwong et al., Nature 393, 648-659 (18 June 1998)