BMPR1A

BMPR1A
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	3QB4, 1ES7, 1REW, 2GOO, 2H62, 2H64, 2K3G, 2QJ9, 2QJA, 2QJB, 3NH7
معین‌کننده‌ها
نام‌های دیگر	BMPR1A, 10q23del, ACVRLK3, ALK3, CD292, SKR5, bone morphogenetic protein receptor type 1A
شناسه‌های بیرونی	OMIM: 601299 MGI: 1338938 HomoloGene: 20911 GeneCards: BMPR1A
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	34,225,298 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • protein homodimerization activity; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • transmembrane receptor protein serine/threonine kinase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • SMAD binding; • ATP binding; • BMP receptor activity; • transforming growth factor beta-activated receptor activity; • transforming growth factor beta receptor activity, type I; • growth factor binding;
ترکیبات سلولی	• integral component of membrane; • HFE-transferrin receptor complex; • membrane; • پوسته یاخته; • neuronal cell body; • دندریت; • حفره غشایی; • external side of plasma membrane; • integral component of plasma membrane; • receptor complex; • cell surface;
فرایند زیستی	• somitogenesis; • pattern specification process; • roof of mouth development; • دگرگونی یاخته‌; • pituitary gland development; • endoderm development; • chondrocyte differentiation; • neural crest cell development; • lateral mesoderm development; • lung development; • positive regulation of bone mineralization; • embryonic organ development; • paraxial mesoderm structural organization; • positive regulation of epithelial cell proliferation; • فسفرگیری; • negative regulation of neurogenesis; • positive regulation of pathway-restricted SMAD protein phosphorylation; • mesoderm formation; • ectoderm development; • embryonic digit morphogenesis; • heart morphogenesis; • cellular response to BMP stimulus; • in utero embryonic development; • BMP signaling pathway; • hindlimb morphogenesis; • جنین‌شناسی دستگاه عصبی مرکزی; • dorsal/ventral axis specification; • regulation of lateral mesodermal cell fate specification; • stem cell population maintenance; • odontogenesis of dentin-containing tooth; • Mullerian duct regression; • endocardial cushion formation; • protein phosphorylation; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • heart development; • غضروف‌زایی; • positive regulation of osteoblast differentiation; • developmental growth; • transmembrane receptor protein serine/threonine kinase signaling pathway; • positive regulation of mesenchymal cell proliferation; • heart formation; • neural plate pattern specification; • embryonic morphogenesis; • mesendoderm development; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • regulation of cellular senescence; • neural plate mediolateral regionalization; • dorsal/ventral pattern formation; • transforming growth factor beta receptor signaling pathway; • positive regulation of SMAD protein signal transduction; • anterior/posterior pattern specification; • paraxial mesoderm development; • positive regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of smooth muscle cell migration; • BMP signaling pathway involved in heart development; • regulation of cardiac muscle cell apoptotic process; • outflow tract septum morphogenesis; • outflow tract morphogenesis; • cardiac conduction system development; • mitral valve morphogenesis; • tricuspid valve morphogenesis; • endocardial cushion morphogenesis; • cardiac right ventricle morphogenesis; • ventricular trabecula myocardium morphogenesis; • ventricular compact myocardium morphogenesis; • dorsal aorta morphogenesis; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • regulation of cardiac muscle cell proliferation; • positive regulation of cardiac muscle cell proliferation; • pharyngeal arch artery morphogenesis; • positive regulation of cardiac ventricle development; • positive regulation of vascular associated smooth muscle cell proliferation; • fibrous ring of heart morphogenesis; • regulation of neural crest cell differentiation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	657
	12166
	ENSG00000107779
	ENSMUSG00000021796
	P36894
	P36895
	NM_004329، XM_011540103 XM_011540104، NM_004329، XM_011540103
	XM_006518469، XM_006518470، XM_036158412، XM_036158413 NM_009758، XM_006518469، XM_006518470، XM_036158412، XM_036158413
	XP_011538405، XP_011538406 NP_004320، XP_011538405، XP_011538406
	XP_006518532، XP_006518533، XP_036014305، XP_036014306 NP_033888، XP_006518532، XP_006518533، XP_036014305، XP_036014306
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده پروتئین ریخت‌زایی استخوان، نوع IA که با نام BMPR1A نیز شناخته می شود، پروتئینی است که در انسان توسط ژن BMPR1A کدگذاری می شود . BMPR1A نیز به عنوان CD292 ( خوشه تمایزی 292) تعیین شده است.^[۴]

لیگاندها ویرایش

آگونیست‌ها: BMP2 ،BMP4 ،BMP6 ،BMP7 ،GDF6
آنتاگونیست‌ها: ناگین، کوردین

فعل و انفعالات ویرایش

نشان داده شده است که BMPR1A با پروتئین‌های زیر تعامل پروتئین-پروتئین دارد:

BMP2،^[۵]^[۶]^[۷]^[۸]
SF3B4،^[۹] و
ZMYND11^[۱۰]

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000021796 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: BMPR1A bone morphogenetic protein receptor, type IA".
↑ Nickel J, Dreyer MK, Kirsch T, Sebald W (2001). "The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists". J Bone Joint Surg Am. 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668.
↑ Kirsch T, Nickel J, Sebald W (February 2000). "Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2". FEBS Lett. 468 (2–3): 215–9. doi:10.1016/s0014-5793(00)01214-x. PMID 10692589.
↑ Kirsch T, Nickel J, Sebald W (July 2000). "BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II". EMBO J. 19 (13): 3314–24. doi:10.1093/emboj/19.13.3314. PMC 313944. PMID 10880444.
↑ Gilboa L, Nohe A, Geissendörfer T, Sebald W, Henis YI, Knaus P (March 2000). "Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors". Mol. Biol. Cell. 11 (3): 1023–35. doi:10.1091/mbc.11.3.1023. PMC 14828. PMID 10712517.
↑ Nishanian TG, Waldman T (October 2004). "Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor". Biochem. Biophys. Res. Commun. 323 (1): 91–7. doi:10.1016/j.bbrc.2004.08.060. PMID 15351706.
↑ Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (April 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660.

جهت مطالعه ویرایش

Liu F, Ventura F, Doody J, Massagué J (1995). "Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs". Mol. Cell. Biol. 15 (7): 3479–86. doi:10.1128/mcb.15.7.3479. PMC 230584. PMID 7791754.
ten Dijke P, Ichijo H, Franzén P, Schulz P, Saras J, Toyoshima H, Heldin CH, Miyazono K (1993). "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity". Oncogene. 8 (10): 2879–87. PMID 8397373.
Ishidou Y, Kitajima I, Obama H, Maruyama I, Murata F, Imamura T, Yamada N, ten Dijke P, Miyazono K, Sakou T (1996). "Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation". J. Bone Miner. Res. 10 (11): 1651–9. doi:10.1002/jbmr.5650101107. PMID 8592941. S2CID 33345688.
Yamada N, Kato M, ten Dijke P, Yamashita H, Sampath TK, Heldin CH, Miyazono K, Funa K (1996). "Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours". Br. J. Cancer. 73 (5): 624–9. doi:10.1038/bjc.1996.108. PMC 2074358. PMID 8605097.
Nishitoh H, Ichijo H, Kimura M, Matsumoto T, Makishima F, Yamaguchi A, Yamashita H, Enomoto S, Miyazono K (1996). "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5". J. Biol. Chem. 271 (35): 21345–52. doi:10.1074/jbc.271.35.21345. PMID 8702914.
Wu X, Robinson CE, Fong HW, Gimble JM (1996). "Analysis of the native murine bone morphogenetic protein serine threonine kinase type I receptor (ALK-3)". J. Cell. Physiol. 168 (2): 453–61. doi:10.1002/(SICI)1097-4652(199608)168:2<453::AID-JCP24>3.0.CO;2-2. PMID 8707881.
Erlacher L, McCartney J, Piek E, ten Dijke P, Yanagishita M, Oppermann H, Luyten FP (1998). "Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis". J. Bone Miner. Res. 13 (3): 383–92. doi:10.1359/jbmr.1998.13.3.383. PMID 9525338. S2CID 25307046.
Zhang D, Mehler MF, Song Q, Kessler JA (1998). "Development of bone morphogenetic protein receptors in the nervous system and possible roles in regulating trkC expression". J. Neurosci. 18 (9): 3314–26. doi:10.1523/JNEUROSCI.18-09-03314.1998. PMC 6792660. PMID 9547239.
Ide H, Saito-Ohara F, Ohnami S, Osada Y, Ikeuchi T, Yoshida T, Terada M (1998). "Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23→q24 byin situ hybridization and radiation hybrid map ping". Cytogenet. Cell Genet. 81 (3–4): 285–6. doi:10.1159/000015048. PMID 9730621. S2CID 46751090.
Souchelnytskyi S, Nakayama T, Nakao A, Morén A, Heldin CH, Christian JL, ten Dijke P (1998). "Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors". J. Biol. Chem. 273 (39): 25364–70. doi:10.1074/jbc.273.39.25364. PMID 9738003.
You L, Kruse FE, Pohl J, Völcker HE (1999). "Bone morphogenetic proteins and growth and differentiation factors in the human cornea". Invest. Ophthalmol. Vis. Sci. 40 (2): 296–311. PMID 9950587.
Aström AK, Jin D, Imamura T, Röijer E, Rosenzweig B, Miyazono K, ten Dijke P, Stenman G (1999). "Chromosomal localization of three human genes encoding bone morphogenetic protein receptors". Mamm. Genome. 10 (3): 299–302. doi:10.1007/s003359900990. PMID 10051328. S2CID 19132542.
Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath TK, Kawabata M, Miyazono K, Imamura T (2000). "Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation". J. Cell Sci. 112 (20): 3519–27. doi:10.1242/jcs.112.20.3519. PMID 10504300.
Kim IY, Lee DH, Ahn HJ, Tokunaga H, Song W, Devereaux LM, Jin D, Sampath TK, Morton RA (2000). "Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues". Cancer Res. 60 (11): 2840–4. PMID 10850425.
Kirsch T, Sebald W, Dreyer MK (2000). "Crystal structure of the BMP-2-BRIA ectodomain complex". Nat. Struct. Biol. 7 (6): 492–6. doi:10.1038/75903. PMID 10881198. S2CID 19403233.
Wan M, Shi X, Feng X, Cao X (2001). "Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression". J. Biol. Chem. 276 (13): 10119–25. doi:10.1074/jbc.M006918200. PMID 11139569.

پیوند به بیرون ویرایش

GeneReviews/NCBI/NIH/UW entry on Juvenile Polyposis Syndrome
BMPR1A protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم BMPR1A انسانی و صفحهٔ جزئیات ژنی BMPR1A در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000021796 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: BMPR1A bone morphogenetic protein receptor, type IA".

[pmid11263668-5] Nickel J, Dreyer MK, Kirsch T, Sebald W (2001). "The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists". J Bone Joint Surg Am. 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668.

[pmid10692589-6] Kirsch T, Nickel J, Sebald W (February 2000). "Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2". FEBS Lett. 468 (2–3): 215–9. doi:10.1016/s0014-5793(00)01214-x. PMID 10692589.

[pmid10880444-7] Kirsch T, Nickel J, Sebald W (July 2000). "BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II". EMBO J. 19 (13): 3314–24. doi:10.1093/emboj/19.13.3314. PMC 313944. PMID 10880444.

[pmid10712517-8] Gilboa L, Nohe A, Geissendörfer T, Sebald W, Henis YI, Knaus P (March 2000). "Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors". Mol. Biol. Cell. 11 (3): 1023–35. doi:10.1091/mbc.11.3.1023. PMC 14828. PMID 10712517.

[pmid15351706-9] Nishanian TG, Waldman T (October 2004). "Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor". Biochem. Biophys. Res. Commun. 323 (1): 91–7. doi:10.1016/j.bbrc.2004.08.060. PMID 15351706.

[pmid9663660-10] Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (April 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660.

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