FZD5

فریزلد ۵ (انگلیسی: Frizzled-5) یک پروتئین است که در انسان توسط ژن «FZD5» کدگذاری می‌شود.

FZD5
معین‌کننده‌ها
نام‌های دیگر	FZD5, C2orf31, HFZ5, frizzled class receptor 5
شناسه‌های بیرونی	OMIM: 601723 MGI: 108571 HomoloGene: 2590 GeneCards: FZD5
موقعیت ژن (موش) کروموزوم کروموزوم ۱ (موش) نوار 1 C2|1 32.74 cM شروع 64,769,717 bp پایان 64,776,910 bp
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • amyloid-beta binding • signal transducer activity • Wnt-protein binding • GO:0001948، GO:0016582 پیوند پروتئینی • protein kinase binding • ubiquitin protein ligase binding • transmembrane signaling receptor activity • Wnt-activated receptor activity • G protein-coupled receptor activity ترکیبات سلولی • clathrin-coated endocytic vesicle membrane • دستگاه گلژی • early endosome membrane • membrane • bicellular tight junction • Golgi membrane • پوسته یاخته • cell surface • early endosome • perinuclear region of cytoplasm • integral component of membrane فرایند زیستی • G protein-coupled receptor signaling pathway • T cell differentiation in thymus • chorionic trophoblast cell differentiation • positive regulation of protein targeting to mitochondrion • positive regulation of JUN kinase activity • apoptotic process involved in morphogenesis • regulation of chorionic trophoblast cell proliferation • regulation of bicellular tight junction assembly • regulation of canonical Wnt signaling pathway • cellular response to molecule of bacterial origin • positive regulation of interferon-gamma production • embryonic axis specification • labyrinthine layer blood vessel development • cell maturation • Wnt signaling pathway • embryonic camera-type eye development • multicellular organism development • cell surface receptor signaling pathway • vasculature development • regulation of autophagy of mitochondrion • branching involved in labyrinthine layer morphogenesis • embryonic camera-type eye morphogenesis • post-embryonic camera-type eye development • positive regulation of T cell cytokine production • رگ‌زایی • neuron differentiation • Wnt signaling pathway involved in dorsal/ventral axis specification • canonical Wnt signaling pathway • سیناپتوژنز • syncytiotrophoblast cell differentiation involved in labyrinthine layer development • anterior/posterior axis specification, embryo • Spemann organizer formation • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • GO:0072468 ورارسانی پیام • Wnt signaling pathway, calcium modulating pathway • Wnt signaling pathway, planar cell polarity pathway • beta-catenin destruction complex disassembly منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	7855	14367
آنسامبل	ENSG00000163251	ENSMUSG00000045005
یونی‌پروت	Q13467	Q9EQD0
RefSeq (mRNA)	NM_003468 NM_030804، NM_003468	NM_001042659، NM_022721 NM_001033193، NM_001042659، NM_022721
RefSeq (پروتئین)	XP_024308898 NP_003459، XP_024308898	NP_073558 NP_001036124، NP_073558
موقعیت (UCSC)	ن/م	Chr : 64.77 – 64.78 Mb
جستجوی PubMed
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

اعضای خانوادهٔ ژن‌های فریزلد، یک گیرنده جفت‌شونده با پروتئین جی با هفت دومین پروتئینی تراغشایی را کد می‌کنند که همگی پروتئین‌های مسیر سیگنالینگ Wnt هستند.

منابع

• مشارکت‌کنندگان ویکی‌پدیا. «FZD5». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۸ دسامبر ۲۰۱۸.

برای مطالعهٔ بیشتر

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