English: Rowen et al.'s proposal for how misprocessing of amyloid precursor protein (APP) leads to decreased long-term potentiation (LTP) and early and late cognitive decline in individuals with Alzheimer disease. From the article: Rowan MJ, Klyubin I, Cullen WK, Anwyl R (April 2003). "Synaptic plasticity in animal models of early Alzheimer's disease". Philosophical transactions of the Royal Society of London. Series B, Biological sciences 358 (1432): 821–8. doi:10.1098/rstb.2002.1240. PMID 12740129. PMC: 1693153, http://journals.royalsociety.org/openurl.asp?genre=article&issn=0962-8436&volume=358&issue=1432&spage=821.