خانه
تصادفی
در نزدیکی
ورود
تنظیمات
کمک مالی
دربارهٔ ویکیپدیا
تکذیبنامهها
جستجو
الگو
:
PBB/10062
زبان
پیگیری
ویرایش
<
الگو:PBB
Nuclear receptor subfamily 1, group H, member 3
PDB
rendering based on 1uhl.
ساختارهای موجود
بانک داده پروتئین
Ortholog search:
PDBe
,
RCSB
فهرست کدهای شناسه PDB
1UHL
,
3IPQ
,
3IPS
,
3IPU
شاخصها
نماد ژن
NR1H3
; LXR-a; LXRA; RLD-1
شناسههای بیرونی
OMIM
:
602423
MGI
:
1352462
HomoloGene
:
21165
IUPHAR
:
NR1H3
ChEMBL
:
2808
GeneCards
:
NR1H3 Gene
هستیشناسی ژن
Molecular function
•
DNA binding
•
steroid hormone receptor activity
•
transcription coactivator activity
•
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
•
protein binding
•
zinc ion binding
•
cholesterol binding
•
sterol response element binding
•
sequence-specific DNA binding
•
transcription regulatory region DNA binding
•
retinoid X receptor binding
•
protein heterodimerization activity
Cellular component
•
nuclear chromatin
•
nucleus
•
nucleoplasm
•
cytoplasm
Biological process
•
negative regulation of transcription from RNA polymerase II promoter
•
transcription initiation from RNA polymerase II promoter
•
insulin receptor signaling pathway
•
gene expression
•
negative regulation of macrophage derived foam cell differentiation
•
positive regulation of triglyceride biosynthetic process
•
positive regulation of receptor biosynthetic process
•
positive regulation of cholesterol efflux
•
negative regulation of cholesterol storage
•
positive regulation of cellular protein metabolic process
•
negative regulation of lipid transport
•
positive regulation of cholesterol transport
•
response to progesterone stimulus
•
positive regulation of toll-like receptor 4 signaling pathway
•
cholesterol homeostasis
•
regulation of circadian rhythm
•
negative regulation of macrophage activation
•
apoptotic cell clearance
•
cellular lipid metabolic process
•
positive regulation of fatty acid biosynthetic process
•
negative regulation of proteolysis
•
positive regulation of transcription, DNA-dependent
•
positive regulation of transcription from RNA polymerase II promoter
•
negative regulation of pinocytosis
•
negative regulation of inflammatory response
•
positive regulation of lipoprotein lipase activity
•
lipid homeostasis
•
sterol homeostasis
•
negative regulation of interferon-gamma-mediated signaling pathway
•
triglyceride homeostasis
•
cellular response to lipopolysaccharide
•
negative regulation of pancreatic juice secretion
•
negative regulation of secretion of lysosomal enzymes
•
positive regulation of cholesterol homeostasis
Sources:
Amigo
/
QuickGO
الگوی بیان RNA
دادهای بیان مرجع بیشتر
اورتولوگ
گونهها
انسان
موش
آنتره
10062
22259
آنسامبل
ENSG00000025434
ENSMUSG00000002108
UniProt
Q13133
Q9Z0Y9
RefSeq (mRNA)
NM_001130101.2
NM_001177730.1
RefSeq (protein)
NP_001123573.1
NP_001171201.1
موقعیت (UCSC)
Chr 11:
47.27 – 47.29 Mb
Chr 2:
91.18 – 91.2 Mb
جستجوی
پابمد
[۱]
[۲]
ن
ب
و