خانه
تصادفی
در نزدیکی
ورود
تنظیمات
کمک مالی
دربارهٔ ویکیپدیا
تکذیبنامهها
جستجو
الگو
:
PBB/1026
زبان
پیگیری
ویرایش
<
الگو:PBB
Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Constructed from
1AXC
ساختارهای موجود
بانک داده پروتئین
Ortholog search:
PDBe
,
RCSB
فهرست کدهای شناسه PDB
1AXC
,
2ZVV
,
2ZVW
شاخصها
نماد ژن
CDKN1A
; CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1
شناسههای بیرونی
OMIM
:
116899
MGI
:
104556
HomoloGene
:
333
ChEMBL
:
5021
GeneCards
:
CDKN1A Gene
هستیشناسی ژن
Molecular function
•
cyclin-dependent protein kinase inhibitor activity
•
protein binding
•
cyclin-dependent protein kinase activating kinase activity
•
cyclin binding
•
metal ion binding
Cellular component
•
cyclin-dependent protein kinase holoenzyme complex
•
nucleus
•
nucleoplasm
•
cytosol
•
PCNA-p21 complex
Biological process
•
cell cycle checkpoint
•
regulation of cyclin-dependent protein kinase activity
•
G1 phase of mitotic cell cycle
•
G1/S transition of mitotic cell cycle
•
S phase of mitotic cell cycle
•
G2/M transition of mitotic cell cycle
•
mitotic cell cycle
•
response to DNA damage stimulus
•
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
•
cell cycle arrest
•
Ras protein signal transduction
•
negative regulation of cell proliferation
•
response to UV
•
response to toxin
•
response to organic nitrogen
•
negative regulation of gene expression
•
response to organic cyclic compound
•
negative regulation of cell growth
•
positive regulation of B cell proliferation
•
organ regeneration
•
cellular response to extracellular stimulus
•
regulation of protein import into nucleus, translocation
•
negative regulation of phosphorylation
•
response to drug
•
negative regulation of apoptotic process
•
negative regulation of cyclin-dependent protein kinase activity
•
positive regulation of anti-apoptosis
•
response to arsenic-containing substance
•
positive regulation of fibroblast proliferation
•
response to corticosterone stimulus
•
response to hyperoxia
•
cellular response to ionizing radiation
•
mitotic cell cycle arrest
•
cellular senescence
•
replicative senescence
•
stress-induced premature senescence
•
regulation of DNA biosynthetic process
•
positive regulation of reactive oxygen species metabolic process
Sources:
Amigo
/
QuickGO
الگوی بیان RNA
دادهای بیان مرجع بیشتر
اورتولوگ
گونهها
انسان
موش
آنتره
1026
12575
آنسامبل
ENSG00000124762
ENSMUSG00000023067
UniProt
P38936
P39689
RefSeq (mRNA)
NM_000389.4
NM_001111099.1
RefSeq (protein)
NP_000380.1
NP_001104569.1
موقعیت (UCSC)
Chr 6:
36.64 – 36.66 Mb
Chr 17:
29.09 – 29.1 Mb
جستجوی
پابمد
[۱]
[۲]
ن
ب
و