الگو:PBB/796

Calcitonin-related polypeptide alpha
Calcitonin-related polypeptide alpha
	NMR solution structure of salmon calcitonin in SDS micelles.
ساختارهای موجود
بانک داده پروتئین	Ortholog search: PDBe, RCSB
فهرست کدهای شناسه PDB
	2JXZ
شاخص‌ها
نماد ژن	CALCA; CALC1; CGRP; CGRP-I; CGRP1; CT; KC
شناسه‌های بیرونی	OMIM: 114130 MGI: 2151253 HomoloGene: 105263 ChEMBL: 5293 GeneCards: CALCA Gene
هستی‌شناسی ژن
Molecular function	• receptor binding; • hormone activity; • protein binding; • calcitonin receptor binding; • protein complex binding;
Cellular component	• extracellular region; • extracellular space; • nucleus; • cytoplasm; • neuronal cell body; • terminal bouton;
Biological process	• endothelial cell proliferation; • vasculature development; • neurological system process involved in regulation of systemic arterial blood pressure; • vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure; • regulation of heart rate; • G-protein coupled receptor internalization; • monocyte chemotaxis; • protein phosphorylation; • inflammatory response; • leukocyte cell-cell adhesion; • adenylate cyclase-activating G-protein coupled receptor signaling pathway; • activation of adenylate cyclase activity; • elevation of cytosolic calcium ion concentration; • neuropeptide signaling pathway; • cell-cell signaling; • embryo implantation; • aging; • feeding behavior; • regulation of blood pressure; • response to heat; • negative regulation of calcium ion transport into cytosol; • negative regulation of ossification; • positive regulation of cAMP biosynthetic process; • receptor internalization; • negative regulation of neurological system process; • activation of protein kinase activity; • positive regulation of interleukin-1 alpha production; • positive regulation of interleukin-8 production; • vasodilation; • endothelial cell migration; • positive regulation of macrophage differentiation; • negative regulation of osteoclast differentiation; • positive regulation of adenylate cyclase activity; • negative regulation of blood pressure; • positive regulation of ossification; • negative regulation of bone resorption; • negative regulation of transcription, DNA-dependent; • positive regulation of vasodilation; • negative regulation of smooth muscle contraction; • response to pain; • regulation of inflammatory response; • detection of temperature stimulus involved in sensory perception of pain; • cytosolic calcium ion homeostasis; • elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;
	Sources: Amigo / QuickGO
الگوی بیان RNA
	دادهای بیان مرجع بیشتر
اورتولوگ
گونه‌ها	انسان
آنتره	796
آنسامبل	ENSG00000110680
UniProt	P01258
RefSeq (mRNA)	NM_001033952
RefSeq (protein)	NP_001029124
موقعیت (UCSC)	Chr 11:; 14.99 – 14.99 Mb
جستجوی پاب‌مد	[۱]
	ن; ب; و;

منابع

↑ پی‌دی‌بی 2glhAndreotti G, Méndez BL, Amodeo P, Morelli MA, Nakamuta H, Motta A (August 2006). "Structural determinants of salmon calcitonin bioactivity: the role of the Leu-based amphipathic alpha-helix". J. Biol. Chem. 281 (34): 24193–203. doi:10.1074/jbc.M603528200. PMID 16766525. {{cite journal}}: Cite has empty unknown parameter: |month= (help)نگهداری یادکرد:نام‌های متعدد:فهرست نویسندگان (link)

[pmid16766525-1] پی‌دی‌بی 2glhAndreotti G, Méndez BL, Amodeo P, Morelli MA, Nakamuta H, Motta A (August 2006). "Structural determinants of salmon calcitonin bioactivity: the role of the Leu-based amphipathic alpha-helix". J. Biol. Chem. 281 (34): 24193–203. doi:10.1074/jbc.M603528200. PMID 16766525. {{cite journal}}: Cite has empty unknown parameter: |month= (help)نگهداری یادکرد:نام‌های متعدد:فهرست نویسندگان (link)

[۱]