وانکومایسین: تفاوت میان نسخهها
محتوای حذفشده محتوای افزودهشده
جز ربات: مرتبسازی ردهها؛ زیباسازی |
قلی زادگان (بحث | مشارکتها) بدون خلاصۀ ویرایش |
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خط ۱:
{{drugbox
| verifiedrevid = 470628926
| IUPAC_name = (1''S'',2''R'',18''R'',19''R'',22''S'',25''R'',28''R'',40''S'')- 48- {[(2''S'',3''R'',4''S'',5''S'',6''R'')- 3- {[(2''S'',4''S'',5''S'',6''S'')- 4- amino- 5- hydroxy- 4,6- dimethyloxan- 2- yl]oxy}- 4,5- dihydroxy- 6- (hydroxymethyl)oxan- 2- yl]oxy}- 22- (carbamoylmethyl)- 5,15- dichloro- 2,18,32,35,37- pentahydroxy- 19- [(2''R'')- 4- methyl- 2- (methylamino)pentanamido]- 20,23,26,42,44- pentaoxo- 7,13- dioxa- 21,24,27,41,43- pentaazaoctacyclo[26.14.2.2<sup>3,6</sup>.2<sup>14,17</sup>.1<sup>8,12</sup>.1<sup>29,33</sup>.0<sup>10,25</sup>.0<sup>34,39</sup>]pentaconta- 3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49- pentadecaene- 40- carboxylic acid
| image = Vancomycin.svg
| width = 300
<!--Clinical data-->
| tradename = Vancocin
| Drugs.com = {{drugs.com|monograph|vancocin}}
| MedlinePlus = a604038
| pregnancy_category = B2 <small>([[Australia|Au]])</small>, B (PO) / C (IV)<small>([[United States|U.S.]])</small>
| legal_AU = S4
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = POM
| legal_US = Rx-only
| legal_status =
| routes_of_administration = [[intravenous|IV]], oral
| licence_US = Vancocin
<!--Pharmacokinetic data-->
| bioavailability = Negligible (oral)
| metabolism = Excreted unchanged
| elimination_half-life = 4–11 hours <small>(adults)</small><br />6-10 days <small>(adults, impaired renal function)</small>
| excretion = Renal
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 1404-90-6
| ATC_prefix = A07
| ATC_suffix = AA09
| ATC_supplemental = {{ATC|J01|XA01}}
| PubChem = 14969
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00512
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 14253
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 6Q205EH1VU
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00212
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 28001
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 262777
<!--Chemical data-->
| C=66 | H=75 | Cl=2 | N=9 | O=24
| molecular_weight = 1449.3 g.mol<sup>-1</sup>
| smiles = C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2Oc3c4cc5cc3Oc6ccc(cc6Cl)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7c8ccc(c(c8)-c9c(cc(cc9O)O)[C@H](NC(=O)[C@H]([C@@H](c1ccc(c(c1)Cl)O4)O)NC7=O)C(=O)O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)CO)O)O)(C)N)O
| InChI = 1/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MYPYJXKWCTUITO-LYRMYLQWSA-N
}}
'''وانکومایسین''' {{انگلیسی|VANCOMYCIN}}
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