باز کردن منو اصلی

گاما انولاز (انگلیسی: Gamma-enolase) که با نام‌های انولاز ۲ و انولاز اختصاصی نرون هم شناخته می‌شود، یک آنزیم است که در انسان توسط ژن «ENO2» کدگذاری می‌شود.[۲][۳]

ENO2
Protein ENO2 PDB 1te6.png
ساختارهای موجود
PDBHuman UniProt search: PDBe RCSB
معین‌کننده‌ها
AliasesENO2, HEL-S-279, NSE, Enolase 2
شناسه‌های بیرونیOMIM: 131360 HomoloGene: 74414 GeneCards: ENO2
RNA expression pattern
PBB GE ENO2 201313 at fs.png
More reference expression data
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001975

n/a

RefSeq (پروتئین)

NP_001966
NP_001966.1

n/a

موقعیت (UCSC)n/an/a
جستجوی PubMed[۱]n/a
ویکی‌داده
مشاهده/ویرایش Human

این آنزیم یکی از ۳ ایزوآنزیمی است که در پستانداران یافت می‌شود.

اهمیت بالینیویرایش

ردیابی این آنزیم با استفاده از آنتی‌بادی، جهت شناسایی یاخته‌های عصبی و سلول‌هایی که تمایز نوروآندوکرین دارند، استفاده می‌شود. این آنزیم در «سرطان ریه با منشأ سلول کوچک» هم یافت می‌شود و می‌توان از آن به‌عنوان یک بیومارکر در تشخیص این نوع سرطان بهره برد.[۴]

 
انولاز اختصاصی نرون در تومور همانژیوبلاستوم مخچه(NSE)

منابعویرایش

  1. "Human PubMed Reference:".
  2. "ENO2 enolase 2 (gamma, neuronal)". NCBI Entrez Gene database.
  3. Online 'Mendelian Inheritance in Man' (OMIM) Enolase 2 -131360
  4. Clegg N, Ferguson C, True LD, Arnold H, Moorman A, Quinn JE, Vessella RL, Nelson PS (April 2003). "Molecular characterization of prostatic small-cell neuroendocrine carcinoma". Prostate. 55 (1): 55–64. doi:10.1002/pros.10217. PMID 12640661.

بیشتر بخوانیدویرایش

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