گیرنده دومین درج کیناز

KDR
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1VR2, 1Y6A, 1Y6B, 1YWN, 2M59, 2MET, 2MEU, 2OH4, 2P2H, 2P2I, 2QU5, 2QU6, 2RL5, 2X1W, 2X1X, 2XIR, 3B8Q, 3B8R, 3BE2, 3C7Q, 3CJF, 3CJG, 3CP9, 3CPB, 3CPC, 3DTW, 3EFL, 3EWH, 3KVQ, 3S35, 3S36, 3S37, 3U6J, 3VHE, 3VHK, 3VID, 3VNT, 3VO3, 3WZD, 3WZE, 4AG8, 4AGC, 4AGD, 4ASD, 4ASE, 5EW3
معین‌کننده‌ها
نام‌های دیگر	KDR, CD309, FLK1, VEGFR, VEGFR2, Kinase insert domain receptor
شناسه‌های بیرونی	OMIM: 191306 MGI: 96683 HomoloGene: 55639 GeneCards: KDR
موقعیت ژن (موش)
کروموزوم	کروموزوم ۵ (موش)
پایان	76,139,118 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • Hsp90 protein binding; • nucleotide binding; • protein kinase activity; • growth factor binding; • vascular endothelial growth factor binding; • kinase activity; • integrin binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • ATP binding; • transmembrane receptor protein tyrosine kinase activity; • vascular endothelial growth factor-activated receptor activity; • protein tyrosine kinase activity; • identical protein binding; • تیروزین کیناز گیرنده‌ای; • transmembrane signaling receptor activity; • cadherin binding;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • دستگاه گلژی; • membrane; • integral component of plasma membrane; • extracellular region; • پیوند میان‌یاخته‌ای; • early endosome; • لیپید رفت; • sorting endosome; • GO:0016023 cytoplasmic vesicle; • هسته یاخته; • اندوزوم; • پوسته یاخته; • شبکه آندوپلاسمی; • receptor complex;
فرایند زیستی	• negative regulation of endothelial cell apoptotic process; • دگرگونی یاخته‌; • positive regulation of protein phosphorylation; • positive regulation of mitochondrial fission; • positive regulation of endothelial cell proliferation; • فسفرگیری; • extracellular matrix organization; • negative regulation of apoptotic process; • positive regulation of nitric-oxide synthase biosynthetic process; • cell migration involved in sprouting angiogenesis; • positive regulation of angiogenesis; • vasculogenesis; • positive regulation of endothelial cell migration; • multicellular organism development; • protein phosphorylation; • positive regulation of macroautophagy; • positive regulation of mitochondrial depolarization; • positive regulation of vasculogenesis; • embryonic hemopoiesis; • endothelium development; • regulation of cell shape; • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; • positive regulation of ERK1 and ERK2 cascade; • peptidyl-tyrosine autophosphorylation; • protein autophosphorylation; • positive regulation of focal adhesion assembly; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • cellular response to vascular endothelial growth factor stimulus; • GO:0022415 viral process; • calcium-mediated signaling using intracellular calcium source; • positive regulation of MAPK cascade; • positive regulation of positive chemotaxis; • transmembrane receptor protein tyrosine kinase signaling pathway; • vascular endothelial growth factor receptor signaling pathway; • positive regulation of cell population proliferation; • رگ‌زایی; • positive regulation of cell migration; • protein kinase B signaling; • ERK1 and ERK2 cascade; • negative regulation of gene expression; • positive regulation of blood vessel endothelial cell migration; • cellular response to hydrogen sulfide; • positive regulation of cell migration involved in sprouting angiogenesis; • negative regulation of signal transduction; • sprouting angiogenesis; • کوچ یاخته; • endothelial cell differentiation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3791
	16542
	ENSG00000128052
	ENSMUSG00000062960
	P35968
	P35918; Q8VCD0
	NM_002253
	XM_011240817، NM_001363216 NM_010612، XM_011240817، NM_001363216
	NP_002244
	XP_011239119، NP_001350145 NP_034742، XP_011239119، NP_001350145
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده دومین درج کیناز (انگلیسی: Kinase insert domain receptor) یا به اختصار «KDR» که با عناوین دیگری چون «گیرندهٔ ۲ فاکتور رشد آندوتلیوم عروق» (VEGFR-2) و «کیناز ۱ کبد جنینی» (Flk1) هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «KDR» کدگذاری می‌شود.

این پروتئین با پروتئین‌های SHC1^[۴]^[۵] و SHC2^[۶]، تعامل پروتئین-پروتئین دارد.

جستارهای وابسته ویرایش

مجموعه تمایزی

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000062960 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zanetti, Adriana; Lampugnani Maria Grazia; Balconi Giovanna; Breviario Ferruccio; Corada Monica; Lanfrancone Luisa; Dejana Elisabetta (April 2002). "Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling". Arterioscler. Thromb. Vasc. Biol. United States. 22 (4): 617–22. doi:10.1161/01.ATV.0000012268.84961.AD. PMID 11950700. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysource= و |laysummary= (help)
↑ D'Angelo, G; Martini J F; Iiri T; Fantl W J; Martial J; Weiner R I (May 1999). "16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells". Mol. Endocrinol. UNITED STATES. 13 (5): 692–704. doi:10.1210/mend.13.5.0280. ISSN 0888-8809. PMID 10319320. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysource= و |laysummary= (help)
↑ Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (April 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. England. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysource= و |laysummary= (help)

مشارکت‌کنندگان ویکی‌پدیا. «Kinase insert domain receptor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۷ ژوئیه ۲۰۱۸.

بیشتر بخوانید ویرایش

Holmes K, Roberts OL, Thomas AM, Cross MJ (October 2007). "Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition". Cell Signal. 19 (10): 2003–2012. doi:10.1016/j.cellsig.2007.05.013. PMID 17658244.
Petrova TV, Makinen T, Alitalo K (1999). "Signaling via vascular endothelial growth factor receptors". Exp. Cell Res. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
Wang J, Fu X, Jiang C, Yu L, Wang M, Han W, Liu L, Wang J (2014). "Bone marrow mononuclear cell transplantation promotes therapeutic angiogenesis via upregulation of the VEGF-VEGFR2 signaling pathway in a rat model of vascular dementia". Behav. Brain Res. 265: 171–180. doi:10.1016/j.bbr.2014.02.033. PMC 4000455. PMID 24589546.
Sato Y, Kanno S, Oda N, et al. (2000). "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction". Ann. N. Y. Acad. Sci. 902 (1): 201–5, discussion 205–7. Bibcode:2000NYASA.902..201S. doi:10.1111/j.1749-6632.2000.tb06314.x. PMID 10865839.
Zachary I, Gliki G (2001). "Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family". Cardiovasc. Res. 49 (3): 568–81. doi:10.1016/S0008-6363(00)00268-6. PMID 11166270.
Vené R, Benelli R, Noonan DM, Albini A (2001). "HIV-Tat dependent chemotaxis and invasion, key aspects of tat mediated pathogenesis". Clin. Exp. Metastasis. 18 (7): 533–8. doi:10.1023/A:1011991906685. PMID 11688957.
Lenton K (2003). "VEGFR-2 (KDR/Flk-1)". J. Biol. Regul. Homeost. Agents. 16 (3): 227–32. PMID 12456025.
Matsumoto T, Mugishima H (2006). "Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis". J. Atheroscler. Thromb. 13 (3): 130–5. doi:10.5551/jat.13.130. PMID 16835467.

پیوند به بیرون ویرایش

Kinase insert domain receptor در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000062960 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11950700-4] Zanetti, Adriana; Lampugnani Maria Grazia; Balconi Giovanna; Breviario Ferruccio; Corada Monica; Lanfrancone Luisa; Dejana Elisabetta (April 2002). "Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling". Arterioscler. Thromb. Vasc. Biol. United States. 22 (4): 617–22. doi:10.1161/01.ATV.0000012268.84961.AD. PMID 11950700. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysource= و |laysummary= (help)

[pmid10319320-5] D'Angelo, G; Martini J F; Iiri T; Fantl W J; Martial J; Weiner R I (May 1999). "16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells". Mol. Endocrinol. UNITED STATES. 13 (5): 692–704. doi:10.1210/mend.13.5.0280. ISSN 0888-8809. PMID 10319320. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysource= و |laysummary= (help)

[pmid10749680-6] Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (April 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. England. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysource= و |laysummary= (help)

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