گیرنده هورمون آزادکننده هورمون رشد

GHRHR
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2XDG
معین‌کننده‌ها
نام‌های دیگر	GHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor, IGHD4
شناسه‌های بیرونی	OMIM: 139191 MGI: 95710 HomoloGene: 640 GeneCards: GHRHR
موقعیت ژن (موش)
کروموزوم	کروموزوم ۶ (موش)
پایان	55,365,515 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• G protein-coupled receptor activity; • growth factor binding; • signal transducer activity; • peptide hormone binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • growth hormone-releasing hormone receptor activity; • transmembrane signaling receptor activity; • G protein-coupled peptide receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • membrane; • ماتریکس هسته ای; • پوسته یاخته; • secretory granule; • cell surface; • nuclear inner membrane; • سارکولما; • nuclear outer membrane;
فرایند زیستی	• adenylate cyclase-activating G protein-coupled receptor signaling pathway; • determination of adult lifespan; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • response to glucocorticoid; • cell maturation; • adenohypophysis development; • water homeostasis; • activation of adenylate cyclase activity; • response to estrogen; • mammary gland development; • response to insulin; • positive regulation of circadian sleep/wake cycle, non-REM sleep; • cell surface receptor signaling pathway; • regulation of insulin-like growth factor receptor signaling pathway; • positive regulation of insulin-like growth factor receptor signaling pathway; • growth hormone secretion; • positive regulation of growth hormone secretion; • positive regulation of cell population proliferation; • positive regulation of multicellular organism growth; • cellular response to insulin stimulus; • somatotropin secreting cell development; • regulation of protein metabolic process; • lactation; • regulation of intracellular steroid hormone receptor signaling pathway; • hormone metabolic process; • positive regulation of hormone secretion; • cAMP-mediated signaling; • cellular response to glucose stimulus; • GO:0072468 ورارسانی پیام; • multicellular organismal reproductive process; • G protein-coupled receptor signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2692
	14602
	ENSG00000106128
	ENSMUSG00000004654
	Q02643
	P32082
	NM_001009824 NM_000823، NM_001009824
	XM_036165843 NM_001003685، XM_036165843
	NP_000814
	XP_036021736 NP_001003685، XP_036021736
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده هورمون آزادکننده هورمون رشد (انگلیسی: Growth-hormone-releasing hormone receptor) نوعی گیرنده جفت‌شونده با پروتئین جی است که به هورمون آزادکننده هورمون رشد اتصال می‌یابد و کارش را از طریق آدنیلات سیکلاز به انجام می‌رساند.^[۴]

این ژن در غدهٔ هیپوفیز بیان می‌شود و در نهایت موجب رهاسازی هورمون رشد می‌گردد.

داروی سی‌جی‌سی ۱۲۹۵ یک آگونیست این گیرنده است.

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000004654 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gaylinn BD (2002). "Growth hormone releasing hormone receptor". Receptors & Channels. 8 (3–4): 155–62. doi:10.1080/10606820213679. PMID 12529933.

مشارکت‌کنندگان ویکی‌پدیا. «Growth-hormone-releasing hormone receptor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳۱ دسامبر ۲۰۱۸.

برای مطالعهٔ بیشتر ویرایش

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Maheshwari HG, Silverman BL, Dupuis J, Baumann G (Nov 1998). "Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh". The Journal of Clinical Endocrinology and Metabolism. 83 (11): 4065–74. doi:10.1210/jc.83.11.4065. PMID 9814493.
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پیوند به بیرون ویرایش

somatotropin releasing hormone receptor در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000004654 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12529933-4] Gaylinn BD (2002). "Growth hormone releasing hormone receptor". Receptors & Channels. 8 (3–4): 155–62. doi:10.1080/10606820213679. PMID 12529933.

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