OGN

OGN
معین‌کننده‌ها
نام‌های دیگر	OGN, OG, OIF, SLRR3A, osteoglycin
شناسه‌های بیرونی	OMIM: 602383 MGI: 109278 HomoloGene: 8542 GeneCards: OGN
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۳ (موش)
پایان	49,777,977 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • growth factor activity; • extracellular matrix structural constituent conferring compression resistance;
ترکیبات سلولی	• extracellular vesicle; • GO:0005578 بافت‌مانه برون‌یاخته‌ای; • lysosomal lumen; • Golgi lumen; • extracellular exosome; • extracellular space; • extracellular region; • collagen-containing extracellular matrix;
فرایند زیستی	• negative regulation of smooth muscle cell proliferation; • axonogenesis; • keratan sulfate catabolic process; • keratan sulfate biosynthetic process; • regulation of signaling receptor activity; • GO:0072468 ورارسانی پیام;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4969
	18295
	ENSG00000106809
	ENSMUSG00000021390
	P20774
	Q62000
	NM_014057، NM_024416 NM_033014، NM_014057، NM_024416
	NM_008760
	NP_077727، NP_148935 NP_054776، NP_077727، NP_148935; NP_148935.1 NP_054776.1، NP_148935.1
	NP_032786
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

اُستئوگلیسین (انگلیسی: Osteoglycin) که با نام «میمیکَن» هم شناخته می‌شود، نام پروتئینی است که در انسان توسط ژن «OGN» کُد می‌شود.^[۴]

این پروتئین در کنار TGF-β موجب استخوان‌سازی نابجا در بافت‌های دیگر می‌شود.

میزان بیان ژنی این پروتئین، با بروز کاردیومگالی و به‌ویژه هیپرتروفی بطن چپ در ارتباط است.^[۵]^[۶]

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000021390 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: OGN osteoglycin".
↑ "Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. Retrieved 2008-06-07.
↑ Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC 2742198. PMID 18443592.

مشارکت‌کنندگان ویکی‌پدیا. «OGN (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۲ دسامبر ۲۰۱۷.

بیشتر بخوانید ویرایش

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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000021390 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: OGN osteoglycin".

[urlBBC_NEWS_|_Health_|_Big_hearts_have_genetic_problem-5] "Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. Retrieved 2008-06-07.

[pmid18443592-6] Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC 2742198. PMID 18443592.

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