TEC

TEC
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2LUL
معین‌کننده‌ها
نام‌های دیگر	TEC, PSCTK4, tec protein tyrosine kinase
شناسه‌های بیرونی	OMIM: 600583 MGI: 98662 HomoloGene: 1302 GeneCards: TEC
موقعیت ژن (موش)
کروموزوم	کروموزوم ۵ (موش)
پایان	73,025,826 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • non-membrane spanning protein tyrosine kinase activity; • metal ion binding; • kinase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • protein tyrosine kinase activity; • signaling receptor binding; • phospholipid binding; • ATP binding; • lipid binding;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • membrane; • extrinsic component of cytoplasmic side of plasma membrane; • اسکلت سلولی; • پوسته یاخته;
فرایند زیستی	• B cell receptor signaling pathway; • دگرگونی یاخته‌; • GO:0007243 intracellular signal transduction; • adaptive immune response; • فسفرگیری; • transmembrane receptor protein tyrosine kinase signaling pathway; • immune system process; • Fc-epsilon receptor signaling pathway; • protein phosphorylation; • regulation of cell population proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • peptidyl-tyrosine autophosphorylation; • integrin-mediated signaling pathway; • peptidyl-tyrosine phosphorylation; • regulation of platelet activation; • دستگاه ایمنی ذاتی; • tissue regeneration; • cytokine-mediated signaling pathway; • T cell receptor signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7006
	21682
	ENSG00000135605
	ENSMUSG00000029217
	P42680
	P24604
	XM_011513737، XM_011513741، XR_925160، XM_017008569، XR_001741318، XR_001741319، XM_024454193 NM_003215، XM_011513737، XM_011513741، XR_925160، XM_017008569، XR_001741318، XR_001741319، XM_024454193
	NM_001113461، NM_001113464، NM_013689، XM_006503845، XM_006503846، XM_006503847، XM_006503848، XM_011240718، XM_011240719، XM_036164992 NM_001113460، NM_001113461، NM_001113464، NM_013689، XM_006503845، XM_006503846، XM_006503847، XM_006503848، XM_011240718، XM_011240719، XM_036164992
	XP_011512039، XP_011512043، XP_016864058، XP_024309961 NP_003206، XP_011512039، XP_011512043، XP_016864058، XP_024309961
	NP_001106932، NP_001106935، NP_038717، XP_006503908، XP_006503909، XP_006503910، XP_006503911، XP_011239020، XP_011239021، XP_036020885 NP_001106931، NP_001106932، NP_001106935، NP_038717، XP_006503908، XP_006503909، XP_006503910، XP_006503911، XP_011239020، XP_011239021، XP_036020885
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

تیروزین -پروتئین کیناز Tec (انگلیسی: Tyrosine-protein kinase Tec) یک آنزیم است که در انسان توسط ژن «TEC» کدگذاری می‌شود.^[۴]^[۵]

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000029217 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (Oct 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia. 8 (10): 1663–72. PMID 7934162.
↑ "Entrez Gene: TEC tec protein tyrosine kinase".

مشارکت‌کنندگان ویکی‌پدیا. «TEC (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۷ اکتبر ۲۰۱۸.

بیشتر بخوانید ویرایش

Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function". Cytokine & Growth Factor Reviews. 10 (3–4): 267–80. doi:10.1016/S1359-6101(99)00019-2. PMID 10647781.
Yang WC, Collette Y, Nunès JA, Olive D (Apr 2000). "Tec kinases: a family with multiple roles in immunity". Immunity. 12 (4): 373–82. doi:10.1016/S1074-7613(00)80189-2. PMID 10795735.
Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F (Dec 1990). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver". Oncogene. 5 (12): 1781–6. PMID 2284097.
Tang B, Mano H, Yi T, Ihle JN (Dec 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Molecular and Cellular Biology. 14 (12): 8432–7. PMC 359382. PMID 7526158.
Machide M, Mano H, Todokoro K (Aug 1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25. PMID 7651724.
Mano H, Yamashita Y, Miyazato A, Miura Y, Ozawa K (Apr 1996). "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase". FASEB Journal. 10 (5): 637–42. PMID 8621063.
Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP (Feb 1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science. 271 (5250): 822–5. doi:10.1126/science.271.5250.822. PMID 8629002.
Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON (May 1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity. 4 (5): 515–25. doi:10.1016/S1074-7613(00)80417-3. PMID 8630736.
Ohta Y, Haire RN, Amemiya CT, Litman RT, Träger T, Riess O, Litman GW (Feb 1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene. 12 (4): 937–42. PMID 8632917.
Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ, Kinnon C, Lovering RC (Nov 1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways". Journal of Immunology. 157 (9): 3791–5. PMID 8892607.
Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.
Laffargue M, Monnereau L, Tuech J, Ragab A, Ragab-Thomas J, Payrastre B, Raynal P, Chap H (Sep 1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets". Biochemical and Biophysical Research Communications. 238 (1): 247–51. doi:10.1006/bbrc.1997.7269. PMID 9299487.
Kitanaka A, Mano H, Conley ME, Campana D (Feb 1998). "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells". Blood. 91 (3): 940–8. PMID 9446655.
Yang WC, Ghiotto M, Barbarat B, Olive D (Jan 1999). "The role of Tec protein-tyrosine kinase in T cell signaling". The Journal of Biological Chemistry. 274 (2): 607–17. doi:10.1074/jbc.274.2.607. PMID 9872994.
Yang WC, Olive D (Jun 1999). "Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway". European Journal of Immunology. 29 (6): 1842–9. doi:10.1002/(SICI)1521-4141(199906)29:06<1842::AID-IMMU1842>3.0.CO;2-D. PMID 10382746.
Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H (Oct 1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proceedings of the National Academy of Sciences of the United States of America. 96 (21): 11976–81. doi:10.1073/pnas.96.21.11976. PMC 18397. PMID 10518561.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000029217 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7934162-4] Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (Oct 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia. 8 (10): 1663–72. PMID 7934162.

[entrez-5] "Entrez Gene: TEC tec protein tyrosine kinase".

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