پروتئین آرآبی۲۷آ

RAB27A
معین‌کننده‌ها
نام‌های دیگر	RAB27A, GS2, HsT18676, RAB27, RAM, member RAS oncogene family
شناسه‌های بیرونی	OMIM: 603868 MGI: 1861441 HomoloGene: 3069 GeneCards: RAB27A
موقعیت ژن (موش)
کروموزوم	کروموزوم ۹ (موش)
پایان	73,004,911 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• nucleotide binding; • protein domain specific binding; • GDP binding; • GTP binding; • myosin V binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0006184 GTPase activity;
ترکیبات سلولی	• جسم وایبل-پالاد; • اندوزوم; • late endosome; • دستگاه گلژی; • multivesicular body membrane; • exocytic vesicle; • secretory granule membrane; • membrane; • melanosome; • photoreceptor outer segment; • secretory granule; • دندریت; • apical plasma membrane; • کافنده‌تن; • extracellular exosome; • extracellular region; • سیتوزول; • melanosome membrane; • specific granule lumen; • سیناپس;
فرایند زیستی	• positive regulation of reactive oxygen species biosynthetic process; • natural killer cell degranulation; • protein targeting; • positive regulation of phagocytosis; • antigen processing and presentation; • multivesicular body sorting pathway; • pigment granule localization; • انعقاد خون; • melanosome localization; • pigment granule transport; • GO:1901313 positive regulation of gene expression; • multivesicular body organization; • melanosome transport; • positive regulation of constitutive secretory pathway; • synaptic vesicle transport; • complement-dependent cytotoxicity; • pigmentation; • cytotoxic T cell degranulation; • exosomal secretion; • positive regulation of exocytosis; • melanocyte differentiation; • vesicle-mediated transport; • positive regulation of regulated secretory pathway; • اگزوسیتوز; • neutrophil degranulation; • intracellular protein transport; • Rab protein signal transduction;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5873
	11891
	ENSG00000069974
	ENSMUSG00000032202
	P51159
	Q9ERI2
	NM_004580، NM_183234، NM_183235، NM_183236، XM_005254576، XM_011521852، XM_011521854، XM_011521855، XM_024450009 XM_011521856، NM_004580، NM_183234، NM_183235، NM_183236، XM_005254576، XM_011521852، XM_011521854، XM_011521855، XM_024450009
	NM_001301232، NM_023635، XM_006510780 NM_001301230، NM_001301232، NM_023635، XM_006510780
	NP_899057، NP_899058، NP_899059، XP_005254633، XP_011520154، XP_011520156، XP_011520157، XP_011520158، XP_024305777 NP_004571، NP_899057، NP_899058، NP_899059، XP_005254633، XP_011520154، XP_011520156، XP_011520157، XP_011520158، XP_024305777
	NP_001288161، NP_076124، XP_006510843 NP_001288159، NP_001288161، NP_076124، XP_006510843
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین Rab-27A مرتبط با Ras (انگلیسی: Ras-related protein Rab-27A) یک پروتئین است که در انسان توسط ژن «RAB27A» کُدگذاری می‌شود.^[۴]^[۵]

پروتئین یادشده، متعلق به خانوادهٔ پروتئین‌های Rab است که خود، جزئی از اَبَـرخانوادهٔ «جی‌تی‌پی‌آزهای کوچک» هستند. ژن «RAB27A» توسط فاکتور رونویسی مرتبط با میکروفتالمی تنظیم می‌شود.^[۶]^[۷]

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000032202 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seabra MC, Ho YK, Anant JS (Dec 1995). "Deficient geranylgeranylation of Ram/Rab27 in choroideremia". J Biol Chem. 270 (41): 24420–7. doi:10.1074/jbc.270.41.24420. PMID 7592656.
↑ "Entrez Gene: RAB27A RAB27A, member RAS oncogene family".
↑ Chiaverini C, Beuret L, Flori E, Busca R, Abbe P, Bille K, Bahadoran P, Ortonne JP, Bertolotto C, Ballotti R (2008). "Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport". J. Biol. Chem. 283 (18): 12635–42. doi:10.1074/jbc.M800130200. PMID 18281284.
↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

مشارکت‌کنندگان ویکی‌پدیا. «RAB27A». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ ژوئن ۲۰۲۰.

برای مطالعهٔ بیشتر ویرایش

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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000032202 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7592656-4] Seabra MC, Ho YK, Anant JS (Dec 1995). "Deficient geranylgeranylation of Ram/Rab27 in choroideremia". J Biol Chem. 270 (41): 24420–7. doi:10.1074/jbc.270.41.24420. PMID 7592656.

[entrez-5] "Entrez Gene: RAB27A RAB27A, member RAS oncogene family".

[pmid18281284-6] Chiaverini C, Beuret L, Flori E, Busca R, Abbe P, Bille K, Bahadoran P, Ortonne JP, Bertolotto C, Ballotti R (2008). "Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport". J. Biol. Chem. 283 (18): 12635–42. doi:10.1074/jbc.M800130200. PMID 18281284.

[pmidunknown-7] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

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