گیرنده ۲ فاکتور نکروز تومور

TNFRSF1B
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1CA9, 3ALQ
معین‌کننده‌ها
نام‌های دیگر	TNFRSF1B, CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR, tumor necrosis factor receptor superfamily member 1B, TNF receptor superfamily member 1B
شناسه‌های بیرونی	OMIM: 191191 MGI: 1314883 HomoloGene: 829 GeneCards: TNFRSF1B
موقعیت ژن (موش)
کروموزوم	کروموزوم ۴ (موش)
پایان	144,973,440 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • ubiquitin protein ligase binding; • tumor necrosis factor-activated receptor activity; • tumor necrosis factor binding;
ترکیبات سلولی	• integral component of membrane; • membrane; • پوسته یاخته; • integral component of plasma membrane; • varicosity; • extracellular region; • آسه; • neuronal cell body; • perinuclear region of cytoplasm; • لیپید رفت; • هسته یاخته; • specific granule membrane; • tumor necrosis factor receptor superfamily complex;
فرایند زیستی	• extrinsic apoptotic signaling pathway; • RNA destabilization; • cellular response to growth factor stimulus; • positive regulation of membrane protein ectodomain proteolysis; • GO:0010260 پیرش; • multicellular organism development; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • regulation of cell population proliferation; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • intrinsic apoptotic signaling pathway in response to DNA damage; • apoptotic signaling pathway; • inflammatory response; • cellular response to lipopolysaccharide; • negative regulation of inflammatory response; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • tumor necrosis factor-mediated signaling pathway; • neutrophil degranulation; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cytokine-mediated signaling pathway; • aortic valve development; • pulmonary valve development; • negative regulation of extracellular matrix constituent secretion; • negative regulation of cardiac muscle hypertrophy; • positive regulation of apoptotic process involved in morphogenesis; • regulation of T cell cytokine production; • regulation of myelination; • regulation of T cell proliferation; • regulation of neuroinflammatory response; • cellular response to tumor necrosis factor; • positive regulation of myelination; • positive regulation of oligodendrocyte differentiation; • negative regulation of cell death; • negative regulation of neuroinflammatory response; • glial cell-neuron signaling; • negative regulation of neuron death; • regulation of RNA biosynthetic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7133
	21938
	ENSG00000028137
	ENSMUSG00000028599
	P20333
	P25119
	NM_001066، XM_011542060، XM_047429422، XM_047429423، XM_047429424 XM_011542063، NM_001066، XM_011542060، XM_047429422، XM_047429423، XM_047429424
	XM_036163965 NM_011610، XM_036163965
	XP_011540362، XP_011540365، XP_016857700، XP_016857703، XP_016857704 NP_001057، XP_011540362، XP_011540365، XP_016857700، XP_016857703، XP_016857704
	XP_036019858 NP_035740، XP_036019858
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده ۲ فاکتور نکروز تومور (انگلیسی: Tumor necrosis factor receptor 2) که با نام‌های اختصاری TNFR2 و CD120b هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «TNFRSF1B» کُدگذاری می‌شود. این گیرنده فاکتور نکروز توموری آلفا (TNFα) متصل می‌شود.^[۴]^[۵]

عملکرد ویرایش

این پروتئین متعلق به ابرخانواده گیرنده‌های فاکتور نکروز تومور است و در آپوپتوز سلولی نقش دارد. در موش‌ها، تخریب این ژن از طریق تحریک مسیرهای آنتی اُکسیداتیو، سبب محافظت سلول‌های عصبی در برابر آپوپتوز می‌گردد.^[۶]

تعامل‌های شیمیایی ویرایش

این پروتئین با مولکول‌های TRAF2^[۷]^[۸]^[۹]^[۱۰]^[۱۱]^[۱۲]^[۱۳] و TTRAP،^[۱۴] تعامل پروتئین-پروتئین دارد.

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028599 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GH, Gatanaga T, Granger GA, Lentz R, Raab H, et al. (June 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor" (PDF). Cell. 61 (2): 361–70. doi:10.1016/0092-8674(90)90816-W. PMID 2158863.
↑ Santee SM, Owen-Schaub LB (October 1996). "Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization". J Biol Chem. 271 (35): 21151–9. doi:10.1074/jbc.271.35.21151. PMID 8702885.
↑ "Entrez Gene: TNFRSF1B tumor necrosis factor receptor superfamily, member 1B". Retrieved 8 May 2017.
↑ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
↑ Song HY, Donner DB (1995). "Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor". Biochem. J. 309 (3): 825–9. doi:10.1042/bj3090825. PMC 1135706. PMID 7639698.
↑ Takeuchi M, Rothe M, Goeddel DV (1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. PMID 8702708.
↑ Hostager BS, Bishop GA (2002). "Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b". J. Immunol. 168 (7): 3318–22. doi:10.4049/jimmunol.168.7.3318. PMID 11907088.
↑ Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854.
↑ Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID 9162022.
↑ Carpentier I, Coornaert B, Beyaert R (2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation". Biochem. Biophys. Res. Commun. 374 (4): 752–7. doi:10.1016/j.bbrc.2008.07.103. PMID 18671942.
↑ Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.

مشارکت‌کنندگان ویکی‌پدیا. «Tumor necrosis factor receptor 2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ اکتبر ۲۰۲۰.

برای مطالعهٔ بیشتر ویرایش

Kollias G, Kontoyiannis D (2003). "Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments". Cytokine Growth Factor Rev. 13 (4–5): 315–21. doi:10.1016/S1359-6101(02)00019-9. PMID 12220546.
Holtmann MH, Schuchmann M, Zeller G, et al. (2003). "The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disorders". Arch. Immunol. Ther. Exp. (Warsz.). 50 (4): 279–88. PMID 12371624.
Horiuchi T, Kiyohara C, Tsukamoto H, et al. (2007). "A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis". Ann. Rheum. Dis. 66 (3): 320–4. doi:10.1136/ard.2006.058917. PMC 1856025. PMID 17028114.

پیوند به بیرون ویرایش

CD120b Antigen در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028599 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2158863-4] Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GH, Gatanaga T, Granger GA, Lentz R, Raab H, et al. (June 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor" (PDF). Cell. 61 (2): 361–70. doi:10.1016/0092-8674(90)90816-W. PMID 2158863.

[pmid8702885-5] Santee SM, Owen-Schaub LB (October 1996). "Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization". J Biol Chem. 271 (35): 21151–9. doi:10.1074/jbc.271.35.21151. PMID 8702885.

[6] "Entrez Gene: TNFRSF1B tumor necrosis factor receptor superfamily, member 1B". Retrieved 8 May 2017.

[pmid14743216-7] Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.

[pmid7639698-8] Song HY, Donner DB (1995). "Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor". Biochem. J. 309 (3): 825–9. doi:10.1042/bj3090825. PMC 1135706. PMID 7639698.

[pmid8702708-9] Takeuchi M, Rothe M, Goeddel DV (1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. PMID 8702708.

[pmid11907088-10] Hostager BS, Bishop GA (2002). "Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b". J. Immunol. 168 (7): 3318–22. doi:10.4049/jimmunol.168.7.3318. PMID 11907088.

[pmid8710854-11] Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854.

[pmid9162022-12] Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID 9162022.

[pmid18671942-13] Carpentier I, Coornaert B, Beyaert R (2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation". Biochem. Biophys. Res. Commun. 374 (4): 752–7. doi:10.1016/j.bbrc.2008.07.103. PMID 18671942.

[pmid10764746-14] Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.

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