گیرنده بتای رتینوئیک اسید

RARB
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1HRA, 1XAP, 4DM6, 4DM8, 4JYG, 4JYH, 4JYI
معین‌کننده‌ها
نام‌های دیگر	RARB, HAP, MCOPS12, NR1B2, RRB2, RARbeta1, retinoic acid receptor beta, RARbeta
شناسه‌های بیرونی	OMIM: 180220 MGI: 97857 HomoloGene: 68100 GeneCards: RARB
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	6,038,924 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• DNA binding; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • metal ion binding; • steroid hormone receptor activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0032403 protein-containing complex binding; • retinoid X receptor binding; • GO:0000975 transcription cis-regulatory region binding; • transcription factor binding; • nuclear receptor coactivator activity; • signaling receptor activity; • GO:0038050، GO:0004886، GO:0038051 nuclear receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • نوکلئوپلاسم; • هسته یاخته; • RNA polymerase II transcription regulator complex;
فرایند زیستی	• growth plate cartilage development; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • عصب‌زایی; • ureteric bud development; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of cartilage development; • multicellular organism growth; • embryonic eye morphogenesis; • positive regulation of programmed cell death; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • retinal pigment epithelium development; • transcription, DNA-templated; • outflow tract septum morphogenesis; • negative regulation of chondrocyte differentiation; • retinoic acid receptor signaling pathway; • regulation of myelination; • retina development in camera-type eye; • positive regulation of neuron differentiation; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • ventricular cardiac muscle cell differentiation; • transcription initiation from RNA polymerase II promoter; • bone development; • embryonic digestive tract development; • striatum development; • GO:0072468 ورارسانی پیام; • negative regulation of cell population proliferation; • glandular epithelial cell development; • steroid hormone mediated signaling pathway; • embryonic hindlimb morphogenesis; • liver development; • multicellular organism development; • hormone-mediated signaling pathway; • دگرگونی یاخته‌; • response to retinoic acid; • response to lipid; • gland development; • bone morphogenesis; • epithelium development; • cellular response to retinoic acid;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5915
	218772
	ENSG00000077092
	ENSMUSG00000017491
	P10826; Q5QHG3
	P22605
	NM_000965، NM_001290216، NM_001290217، NM_001290266، NM_001290276، NM_001290277، NM_001290300، NM_016152، NR_110892 NR_110893، NM_000965، NM_001290216، NM_001290217، NM_001290266، NM_001290276، NM_001290277، NM_001290300، NM_016152، NR_110892
	NM_001289761، NM_001289762، NM_011243 NM_001289760، NM_001289761، NM_001289762، NM_011243
	NP_001277145، NP_001277146، NP_001277195، NP_001277205، NP_001277206، NP_001277229، NP_057236 NP_000956، NP_001277145، NP_001277146، NP_001277195، NP_001277205، NP_001277206، NP_001277229، NP_057236; NP_001277205.1، NP_057236.1 NP_001277146.1، NP_001277205.1، NP_057236.1
	NP_001276690، NP_001276691، NP_035373 NP_001276689، NP_001276690، NP_001276691، NP_035373
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده بتای رتینوئیک اسید (انگلیسی: Retinoic acid receptor beta) یا به اختصار RAR-beta، یک پروتئین است که در انسان توسط ژن «RARB» کُدگذاری می‌شود.^[۴]^[۵]

این پروتئین، یک گیرنده هسته‌ای، و یکی از انواع گیرنده‌های رتینوئیک اسید است و نخستین بار، در سرطان کبد (از نوعِ هپاتوسلولار) کشف شد.

اختلال در این ژن همچنین، در ضایعات پیش‌سرطانی سرطان دهانه رحم^[۶] و نیز در سرطان مهبل ناشی از لیکن اسکلروز مهبل^[۷] مشاهده شده‌است.

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000017491 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RARB retinoic acid receptor, beta".
↑ Mattei MG, de Thé H, Mattei JF, Marchio A, Tiollais P, Dejean A (Oct 1988). "Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3". Human Genetics. 80 (2): 189–90. doi:10.1007/BF00702867. PMID 2844650.
↑ Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602.
↑ Rotondo JC, Borghi A, Selvatici R, Mazzoni E, Bononi I, Corazza M, Kussini J, Montinari E, Gafà R, Tognon M, Martini F (2018). "Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma". JAMA Dermatology. 154 (7): 819–823. doi:10.1001/jamadermatol.2018.1373. PMC 6128494. PMID 29898214.

مشارکت‌کنندگان ویکی‌پدیا. «Retinoic acid receptor beta». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۲۰.

برای مطالعهٔ بیشتر ویرایش

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Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA (Sep 1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Molecular Endocrinology. 6 (9): 1468–78. doi:10.1210/me.6.9.1468. PMID 1331778.
van der Leede BJ, Folkers GE, Kruyt FA, van der Saag PT (Oct 1992). "Genomic organization of the human retinoic acid receptor beta 2". Biochemical and Biophysical Research Communications. 188 (2): 695–702. doi:10.1016/0006-291X(92)91112-4. PMID 1332705.
Prentice A, Matthews CJ, Thomas EJ, Redfern CP (May 1992). "The expression of retinoic acid receptors in cultured human endometrial stromal cells and effects of retinoic acid". Human Reproduction. 7 (5): 692–700. doi:10.1093/oxfordjournals.humrep.a137721. PMID 1379266.
Shen S, Kruyt FA, den Hertog J, van der Saag PT, Kruijer W (1992). "Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness". DNA Sequence. 2 (2): 111–9. doi:10.3109/10425179109039679. PMID 1663808.
de Thé H, Vivanco-Ruiz MM, Tiollais P, Stunnenberg H, Dejean A (Jan 1990). "Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene". Nature. 343 (6254): 177–80. doi:10.1038/343177a0. PMID 2153268.
Hoffmann B, Lehmann JM, Zhang XK, Hermann T, Husmann M, Graupner G, Pfahl M (Nov 1990). "A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter". Molecular Endocrinology. 4 (11): 1727–36. doi:10.1210/mend-4-11-1727. PMID 2177841.
de Thé H, Marchio A, Tiollais P, Dejean A (1988). "A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma". Nature. 330 (6149): 667–70. doi:10.1038/330667a0. PMID 2825037.
Brand N, Petkovich M, Krust A, Chambon P, de Thé H, Marchio A, Tiollais P, Dejean A (Apr 1988). "Identification of a second human retinoic acid receptor". Nature. 332 (6167): 850–3. doi:10.1038/332850a0. PMID 2833708.
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Houle B, Pelletier M, Wu J, Goodyer C, Bradley WE (Jan 1994). "Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines". Cancer Research. 54 (2): 365–9. PMID 8275470.
Knegtel RM, Katahira M, Schilthuis JG, Bonvin AM, Boelens R, Eib D, van der Saag PT, Kaptein R (Jan 1993). "The solution structure of the human retinoic acid receptor-beta DNA-binding domain". Journal of Biomolecular NMR. 3 (1): 1–17. doi:10.1007/BF00242472. PMID 8383553.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000017491 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: RARB retinoic acid receptor, beta".

[pmid2844650-5] Mattei MG, de Thé H, Mattei JF, Marchio A, Tiollais P, Dejean A (Oct 1988). "Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3". Human Genetics. 80 (2): 189–90. doi:10.1007/BF00702867. PMID 2844650.

[Rotondo_2015-6] Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602.

[Rotondo_2018-7] Rotondo JC, Borghi A, Selvatici R, Mazzoni E, Bononi I, Corazza M, Kussini J, Montinari E, Gafà R, Tognon M, Martini F (2018). "Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma". JAMA Dermatology. 154 (7): 819–823. doi:10.1001/jamadermatol.2018.1373. PMC 6128494. PMID 29898214.

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