PRDX5

PRDX5
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1H4O, 1HD2, 1OC3, 1URM, 2VL2, 2VL3, 2VL9, 3MNG, 4K7I, 4K7N, 4K7O, 4MMM
معین‌کننده‌ها
نام‌های دیگر	PRDX5, ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, prx-V, SBBI10, peroxiredoxin 5
شناسه‌های بیرونی	OMIM: 606583 MGI: 1859821 HomoloGene: 8076 GeneCards: PRDX5
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۹ (موش)
پایان	6,887,474 bp
هستی‌شناسی ژن
عملکرد ملکولی	• peroxynitrite reductase activity; • protein dimerization activity; • peroxidase activity; • RNA polymerase III transcription regulatory region sequence-specific DNA binding; • cysteine-type endopeptidase inhibitor activity involved in apoptotic process; • antioxidant activity; • peroxiredoxin activity; • oxidoreductase activity; • signaling receptor binding; • thioredoxin peroxidase activity; • GO:0001948، GO:0016582 پیوند پروتئینی;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • intracellular membrane-bounded organelle; • پراکسیتن; • mitochondrial matrix; • میتوکندری; • perinuclear region of cytoplasm; • extracellular exosome; • GO:0016023 cytoplasmic vesicle; • هسته یاخته; • extracellular space; • peroxisomal matrix;
فرایند زیستی	• positive regulation of collagen biosynthetic process; • NADPH oxidation; • negative regulation of apoptotic process; • GO:0001306 پاسخ به استرس اکسیداتیو; • GO:0072353 cellular response to reactive oxygen species; • regulation of apoptosis involved in tissue homeostasis; • negative regulation of transcription by RNA polymerase III; • GO:2001216 negative regulation of oxidoreductase activity; • hydrogen peroxide catabolic process; • reactive nitrogen species metabolic process; • inflammatory response; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cellular oxidant detoxification; • cell redox homeostasis; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • cellular response to oxidative stress;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	25824
	54683
	ENSG00000126432
	ENSMUSG00000024953
	P30044
	P99029
	NM_181651، NM_181652، NM_001358511، NM_001358516 NM_012094، NM_181651، NM_181652، NM_001358511، NM_001358516
	NM_001358444 NM_012021، NM_001358444
	NP_857634، NP_857635، NP_001345440، NP_001345445 NP_036226، NP_857634، NP_857635، NP_001345440، NP_001345445
	NP_001345373 NP_036151، NP_001345373
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروکسی‌ردوکسین ۵ (انگلیسی: Peroxiredoxin-5) یک پروتئین است که در انسان توط ژن «PRDX5» کدگذاری می‌شود. این ژن بر روی کروموزوم ۱۱ واقع شده‌است.^[۴] این پروتئین یکی از ۶ عضو خانوادهٔ آنزیم‌های آنتی‌اکسیدان پروکسی‌ردوکسین است.

پروکسی‌ردوکسین ۵ در سطح گسترده‌ای در بدن وجود دارد و جایگاه آن در میتوکندری، پراکسی‌زوم، سیتوزول و هسته یاخته است.^[۵]

اهمیت بالینی ویرایش

کُنز و همکاران با بررسی ۹۸ بیمار مبتلا به سکته مغزی نشان دادند که سطح پروکسی‌ردوکسین ۵ به‌طور معکوس با پیشرفت سکته مغزی مربوط است و بدین ترتیب، شاید بتوان از پروکسی‌ردوکسین ۵ به عنوان یک نشانگر زیستی جهت التهاب در سکته‌های حاد مغزی استفاده نمود.^[۶]

در سرطان پستان انسان، از بین رفتن فاکتور رونویسی GATA1 منجر به افزایش بیان پروکسی‌ردوکسین ۵ و مهار آپوپتوز می‌گردد.^[۷] همچنین افزایش قابل‌توجه پروکسی‌ردوکسین ۵ در آستروسیت‌های موجود در ضایعات مغزی-عصبی در بیماری ام‌اس دیده می‌شود.^[۸] احتمال می‌رود ژن PRDX5 در بروز سارکوئیدوز هم دخیل باشد.^[۹]

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024953 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "PRDX5 peroxiredoxin 5 [Homo sapiens (human)]". NCBI. Retrieved 2016-07-19.
↑ Knoops B, Goemaere J, Van der Eecken V, Declercq JP (August 2011). "Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin". Antioxidants & Redox Signaling. 15 (3): 817–29. doi:10.1089/ars.2010.3584. PMID 20977338.
↑ Kunze A, Zierath D, Tanzi P, Cain K, Becker K (February 2014). "Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke". Stroke. 45 (2): 608–10. doi:10.1161/STROKEAHA.113.003813. PMC 3946812. PMID 24385276.
↑ Seo MS, Kang SW, Kim K, Baines IC, Lee TH, Rhee SG (July 2000). "Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate". The Journal of Biological Chemistry. 275 (27): 20346–54. doi:10.1074/jbc.M001943200. PMID 10751410.
↑ Holley JE, Newcombe J, Winyard PG, Gutowski NJ (September 2007). "Peroxiredoxin V in multiple sclerosis lesions: predominant expression by astrocytes". Multiple Sclerosis. 13 (8): 955–61. doi:10.1177/1352458507078064. PMID 17623739.
↑ Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede KI, Schürmann M, Lipinski S, Rosenstiel P, Zissel G, Höhne K, Petrek M, Kolek V, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Gieger C, Wichmann HE, Nebel A, Franke A, Müller-Quernheim J, Hofmann S, Schreiber S (November 2012). "A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1". American Journal of Respiratory and Critical Care Medicine. 186 (9): 877–85. doi:10.1164/rccm.201204-0708OC. PMID 22837380.

مشارکت‌کنندگان ویکی‌پدیا. «PRDX5». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۶ آوریل ۲۰۱۸.

برای مطالعهٔ بیشتر ویرایش

Wood ZA, Schröder E, Robin Harris J, Poole LB (January 2003). "Structure, mechanism and regulation of peroxiredoxins". Trends in Biochemical Sciences. 28 (1): 32–40. doi:10.1016/S0968-0004(02)00003-8. PMID 12517450.
Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (December 1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669.
Kropotov A, Sedova V, Ivanov V, Sazeeva N, Tomilin A, Krutilina R, Oei SL, Griesenbeck J, Buchlow G, Tomilin N (March 1999). "A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro". European Journal of Biochemistry. 260 (2): 336–46. doi:10.1046/j.1432-1327.1999.00162.x. PMID 10095767.
Wattiez R, Hermans C, Bernard A, Lesur O, Falmagne P (June 1999). "Human bronchoalveolar lavage fluid: two-dimensional gel electrophoresis, amino acid microsequencing and identification of major proteins". Electrophoresis. 20 (7): 1634–45. doi:10.1002/(SICI)1522-2683(19990601)20:7<1634::AID-ELPS1634>3.0.CO;2-J. PMID 10424490.
Zhou Y, Kok KH, Chun AC, Wong CM, Wu HW, Lin MC, Fung PC, Kung H, Jin DY (February 2000). "Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis". Biochemical and Biophysical Research Communications. 268 (3): 921–7. doi:10.1006/bbrc.2000.2231. PMID 10679306.
Seo MS, Kang SW, Kim K, Baines IC, Lee TH, Rhee SG (July 2000). "Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate". The Journal of Biological Chemistry. 275 (27): 20346–54. doi:10.1074/jbc.M001943200. PMID 10751410.
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (August 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. JSTOR 123500. PMC 16901. PMID 10931946.
Declercq JP, Evrard C, Clippe A, Stricht DV, Bernard A, Knoops B (August 2001). "Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution". Journal of Molecular Biology. 311 (4): 751–9. doi:10.1006/jmbi.2001.4853. PMID 11518528.
Rouhier N, Gelhaye E, Jacquot JP (April 2002). "Glutaredoxin-dependent peroxiredoxin from poplar: protein-protein interaction and catalytic mechanism". The Journal of Biological Chemistry. 277 (16): 13609–14. doi:10.1074/jbc.M111489200. PMID 11832487.
Wang MX, Wei A, Yuan J, Trickett A, Knoops B, Murrell GA (November 2002). "Expression and regulation of peroxiredoxin 5 in human osteoarthritis". FEBS Letters. 531 (2): 359–62. doi:10.1016/S0014-5793(02)03511-1. PMID 12417342.
Leyens G, Donnay I, Knoops B (December 2003). "Cloning of bovine peroxiredoxins-gene expression in bovine tissues and amino acid sequence comparison with rat, mouse and primate peroxiredoxins". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 136 (4): 943–55. doi:10.1016/S1096-4959(03)00290-2. PMID 14662316.
Banmeyer I, Marchand C, Verhaeghe C, Vucic B, Rees JF, Knoops B (January 2004). "Overexpression of human peroxiredoxin 5 in subcellular compartments of Chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides". Free Radical Biology & Medicine. 36 (1): 65–77. doi:10.1016/j.freeradbiomed.2003.10.019. PMID 14732291.
Salmon M, Dedessus Le Moutier J, Wenders F, Chiarizia S, Eliaers F, Remacle J, Royer V, Pascal T, Toussaint O (January 2004). "Role of the PLA2-independent peroxiredoxin VI activity in the survival of immortalized fibroblasts exposed to cytotoxic oxidative stress". FEBS Letters. 557 (1–3): 26–32. doi:10.1016/S0014-5793(03)01437-6. PMID 14741336.
Evrard C, Capron A, Marchand C, Clippe A, Wattiez R, Soumillion P, Knoops B, Declercq JP (April 2004). "Crystal structure of a dimeric oxidized form of human peroxiredoxin 5". Journal of Molecular Biology. 337 (5): 1079–90. doi:10.1016/j.jmb.2004.02.017. PMID 15046979.
Yuan J, Murrell GA, Trickett A, Landtmeters M, Knoops B, Wang MX (July 2004). "Overexpression of antioxidant enzyme peroxiredoxin 5 protects human tendon cells against apoptosis and loss of cellular function during oxidative stress". Biochimica et Biophysica Acta. 1693 (1): 37–45. doi:10.1016/j.bbamcr.2004.04.006. PMID 15276323.
Dubuisson M, Vander Stricht D, Clippe A, Etienne F, Nauser T, Kissner R, Koppenol WH, Rees JF, Knoops B (July 2004). "Human peroxiredoxin 5 is a peroxynitrite reductase". FEBS Letters. 571 (1–3): 161–5. doi:10.1016/j.febslet.2004.06.080. PMID 15280035.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024953 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "PRDX5 peroxiredoxin 5 [Homo sapiens (human)]". NCBI. Retrieved 2016-07-19.

[Knoops_2011-5] Knoops B, Goemaere J, Van der Eecken V, Declercq JP (August 2011). "Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin". Antioxidants & Redox Signaling. 15 (3): 817–29. doi:10.1089/ars.2010.3584. PMID 20977338.

[6] Kunze A, Zierath D, Tanzi P, Cain K, Becker K (February 2014). "Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke". Stroke. 45 (2): 608–10. doi:10.1161/STROKEAHA.113.003813. PMC 3946812. PMID 24385276.

[Zitzler_2004-7] Seo MS, Kang SW, Kim K, Baines IC, Lee TH, Rhee SG (July 2000). "Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate". The Journal of Biological Chemistry. 275 (27): 20346–54. doi:10.1074/jbc.M001943200. PMID 10751410.

[8] Holley JE, Newcombe J, Winyard PG, Gutowski NJ (September 2007). "Peroxiredoxin V in multiple sclerosis lesions: predominant expression by astrocytes". Multiple Sclerosis. 13 (8): 955–61. doi:10.1177/1352458507078064. PMID 17623739.

[9] Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede KI, Schürmann M, Lipinski S, Rosenstiel P, Zissel G, Höhne K, Petrek M, Kolek V, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Gieger C, Wichmann HE, Nebel A, Franke A, Müller-Quernheim J, Hofmann S, Schreiber S (November 2012). "A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1". American Journal of Respiratory and Critical Care Medicine. 186 (9): 877–85. doi:10.1164/rccm.201204-0708OC. PMID 22837380.

[۴]

[۱]

[۲]

[۳]

[۵]

[۶]

[۷]

[۸]

[۹]