RRAGA

RRAGA
معین‌کننده‌ها
نام‌های دیگر	RRAGA, FIP-1, FIP1, RAGA, Ras related GTP binding A
شناسه‌های بیرونی	OMIM: 612194 MGI: 1915691 HomoloGene: 68522 GeneCards: RRAGA
موقعیت ژن (موش)
کروموزوم	کروموزوم ۴ (موش)
پایان	86,495,522 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• nucleotide binding; • protein homodimerization activity; • GTP binding; • phosphoprotein binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0006184 GTPase activity; • ubiquitin protein ligase binding; • protein heterodimerization activity;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • GATOR1 complex; • lysosomal membrane; • کافنده‌تن; • هسته یاخته; • Gtr1-Gtr2 GTPase complex;
فرایند زیستی	• cellular response to amino acid starvation; • مرگ یاخته; • positive regulation of cytolysis; • positive regulation of TORC1 signaling; • modulation by virus of host process; • cellular response to amino acid stimulus; • GO:0022415 viral process; • negative regulation of autophagy; • positive regulation of TOR signaling; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • protein ubiquitination; • regulation of macroautophagy; • cellular response to starvation; • regulation of autophagy;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	10670
	68441
	ENSG00000155876
	ENSMUSG00000070934
	Q7L523
	Q80X95
	NM_006570
	NM_178376
	NP_006561
	NP_848463
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین A متصل‌شونده به جی‌تی‌پی مرتبط با آرای‌اس(انگلیسی: Ras-related GTP-binding protein A) یک پروتئین است که در انسان توسط ژن «RRAGA» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000070934 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schürmann A, Brauers A, Massmann S, Becker W, Joost HG (Dec 1995). "Cloning of a novel family of mammalian GTP-binding proteins (raga d, RagBs, RagB1) with remote similarity to the Ras-related GTPases". The Journal of Biological Chemistry. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
↑ Li Y, Kang J, Horwitz MS (Feb 1997). "Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers". Journal of Virology. 71 (2): 1576–82. doi:10.1128/JVI.71.2.1576-1582.1997. PMC 191215. PMID 8995684.
↑ "Entrez Gene: RRAGA Ras-related GTP binding A".

برای مطالعهٔ بیشتر

Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Jan 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". Journal of Cell Science. 111 ( Pt 1) (1): 11–21. doi:10.1242/jcs.111.1.11. PMID 9394008.
Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000070934 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7499430-4] Schürmann A, Brauers A, Massmann S, Becker W, Joost HG (Dec 1995). "Cloning of a novel family of mammalian GTP-binding proteins (raga d, RagBs, RagB1) with remote similarity to the Ras-related GTPases". The Journal of Biological Chemistry. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.

[pmid8995684-5] Li Y, Kang J, Horwitz MS (Feb 1997). "Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers". Journal of Virology. 71 (2): 1576–82. doi:10.1128/JVI.71.2.1576-1582.1997. PMC 191215. PMID 8995684.

[entrez-6] "Entrez Gene: RRAGA Ras-related GTP binding A".

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