TLN1

TLN1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1SYQ, 2MWN, 4DJ9
معین‌کننده‌ها
نام‌های دیگر	TLN1, ILWEQ, TLN, talin 1, talin-1
شناسه‌های بیرونی	OMIM: 186745 MGI: 1099832 HomoloGene: 21267 GeneCards: TLN1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۴ (موش)
پایان	43,562,691 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• structural constituent of cytoskeleton; • actin filament binding; • LIM domain binding; • integrin binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • vinculin binding; • GO:0032403 protein-containing complex binding; • actin binding; • cadherin binding; • phosphatidylserine binding; • phosphatidylinositol binding;
ترکیبات سلولی	• اسکلت سلولی; • cell projection; • ruffle membrane; • ruffle; • سیتوزول; • extracellular exosome; • membrane; • cell surface; • cell-cell junction; • پیوند میان‌یاخته‌ای; • focal adhesion; • extracellular region; • سیتوپلاسم; • پوسته یاخته;
فرایند زیستی	• cell-substrate junction assembly; • IRE1-mediated unfolded protein response; • کشش ماهیچه; • platelet degranulation; • platelet aggregation; • cell-cell junction assembly; • GO:0033109 cortical actin cytoskeleton organization; • چسبندگی سلولی; • GO:0022415 viral process; • integrin-mediated signaling pathway; • integrin activation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7094
	21894
	ENSG00000137076
	ENSMUSG00000028465
	Q9Y490
	P26039
	NM_006289
	XM_006537768، XM_006537769، XM_006537770، XM_036163962، XM_036163963 NM_011602، XM_006537768، XM_006537769، XM_006537770، XM_036163962، XM_036163963
	NP_006280
	XP_006537831، XP_006537832، XP_006537833، XP_036019855، XP_036019856 NP_035732، XP_006537831، XP_006537832، XP_006537833، XP_036019855، XP_036019856
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

تالین ۱ (انگلیسی: TLN1) یک پروتئین است که در انسان توسط ژن «TLN1» کُدگذاری می‌شود.^[۴]^[۵]

تالین ۱ در همه‌جا بیان می‌شود و در ساختار کوستامر در ماهیچه‌های اسکلتی و قلبی و همچنین چسبندگی‌های کانونی در ماهیچه‌های صاف و سلول‌های غیرماهیچه‌ای حضور دارد.

این پروتئین در انسان ۲۷۰٫۰ وزن دارد و از ۲۵۴۱ اسید آمینه تشکیل شده‌است.^[۶]

تالین ۱ میانجیِ چسبندگی سلولی از طریق پیوند دادنِ اینتگرین با اکتین در چارچوب یاخته و همچنین فعال‌سازی اینتگرین است.

اهمیت بالینی

بیان ژنی تالین ۱ در مبتلایان به نارسایی قلب افزایش یافته‌است.^[۷] با این حال، جهش در این ژن را تاکنون به هیچ بیماری خاصی نسبت نداده‌اند.

تعامل‌ها

تالین ۱ با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

جستارهای وابسته

تالین

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028465 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gilmore AP, Ohanian V, Spurr NK, Critchley DR (Aug 1995). "Localisation of the human gene encoding the cytoskeletal protein talin to chromosome 9p". Human Genetics. 96 (2): 221–4. doi:10.1007/BF00207384. PMID 7635475.
↑ Ben-Yosef T, Francomano CA (Dec 1999). "Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern". Genomics. 62 (2): 316–9. doi:10.1006/geno.1999.6019. PMID 10610730.
↑ "Protein sequence of human TLN1 (Uniprot ID: Q9Y490)". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 8 July 2015. Retrieved 7 July 2015.
↑ Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS (Feb 2013). "Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload". The Journal of Biological Chemistry. 288 (6): 4252–64. doi:10.1074/jbc.M112.427484. PMC 3567677. PMID 23266827.
↑ Patil S, Jedsadayanmata A, Wencel-Drake JD, Wang W, Knezevic I, Lam SC (Oct 1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". The Journal of Biological Chemistry. 274 (40): 28575–83. doi:10.1074/jbc.274.40.28575. PMID 10497223.
↑ Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH (Jun 2002). "The phosphotyrosine binding-like domain of talin activates integrins". The Journal of Biological Chemistry. 277 (24): 21749–58. doi:10.1074/jbc.M111996200. PMID 11932255.
↑ Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH (Oct 1999). "The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation". The Journal of Biological Chemistry. 274 (40): 28071–4. doi:10.1074/jbc.274.40.28071. PMID 10497155.
↑ Salgia R, Sattler M, Pisick E, Li JL, Griffin JD (Feb 1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Experimental Hematology. 24 (2): 310–3. PMID 8641358.
↑ Mazaki Y, Hashimoto S, Sabe H (Mar 1997). "Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins". The Journal of Biological Chemistry. 272 (11): 7437–44. doi:10.1074/jbc.272.11.7437. PMID 9054445.
↑ Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y, Pisick E, Hallek M, Ernst T (Mar 1995). "Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL". The Journal of Biological Chemistry. 270 (10): 5039–47. doi:10.1074/jbc.270.10.5039. PMID 7534286.
↑ Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL (Jul 1995). "Interaction of focal adhesion kinase with cytoskeletal protein talin". The Journal of Biological Chemistry. 270 (28): 16995–9. doi:10.1074/jbc.270.28.16995. PMID 7622520.
↑ Zheng C, Xing Z, Bian ZC, Guo C, Akbay A, Warner L, Guan JL (Jan 1998). "Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion". The Journal of Biological Chemistry. 273 (4): 2384–9. doi:10.1074/jbc.273.4.2384. PMID 9442086.
↑ Bass MD, Smith BJ, Prigent SA, Critchley DR (Jul 1999). "Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix". The Biochemical Journal. 341 (2): 257–63. doi:10.1042/bj3410257. PMC 1220354. PMID 10393080.
↑ Gilmore AP, Wood C, Ohanian V, Jackson P, Patel B, Rees DJ, Hynes RO, Critchley DR (Jul 1993). "The cytoskeletal protein talin contains at least two distinct vinculin binding domains". The Journal of Cell Biology. 122 (2): 337–47. doi:10.1083/jcb.122.2.337. PMC 2119638. PMID 8320257.
↑ Burridge K, Mangeat P (1984). "An interaction between vinculin and talin". Nature. 308 (5961): 744–6. doi:10.1038/308744a0. PMID 6425696.

مشارکت‌کنندگان ویکی‌پدیا. «TLN1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۵ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

Luna EJ, Hitt AL (Nov 1992). "Cytoskeleton--plasma membrane interactions". Science. 258 (5084): 955–64. doi:10.1126/science.1439807. PMID 1439807.
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Critchley DR (Nov 2004). "Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion". Biochemical Society Transactions. 32 (Pt 5): 831–6. doi:10.1042/BST0320831. PMID 15494027.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028465 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7635475-4] Gilmore AP, Ohanian V, Spurr NK, Critchley DR (Aug 1995). "Localisation of the human gene encoding the cytoskeletal protein talin to chromosome 9p". Human Genetics. 96 (2): 221–4. doi:10.1007/BF00207384. PMID 7635475.

[pmid10610730-5] Ben-Yosef T, Francomano CA (Dec 1999). "Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern". Genomics. 62 (2): 316–9. doi:10.1006/geno.1999.6019. PMID 10610730.

[6] "Protein sequence of human TLN1 (Uniprot ID: Q9Y490)". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 8 July 2015. Retrieved 7 July 2015.

[Manso_2013-7] Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS (Feb 2013). "Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload". The Journal of Biological Chemistry. 288 (6): 4252–64. doi:10.1074/jbc.M112.427484. PMC 3567677. PMID 23266827.

[Patil_1999-8] Patil S, Jedsadayanmata A, Wencel-Drake JD, Wang W, Knezevic I, Lam SC (Oct 1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". The Journal of Biological Chemistry. 274 (40): 28575–83. doi:10.1074/jbc.274.40.28575. PMID 10497223.

[Calderwood_2002-9] Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH (Jun 2002). "The phosphotyrosine binding-like domain of talin activates integrins". The Journal of Biological Chemistry. 277 (24): 21749–58. doi:10.1074/jbc.M111996200. PMID 11932255.

[Calderwood_1999-10] Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH (Oct 1999). "The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation". The Journal of Biological Chemistry. 274 (40): 28071–4. doi:10.1074/jbc.274.40.28071. PMID 10497155.

[pmid8641358-11] Salgia R, Sattler M, Pisick E, Li JL, Griffin JD (Feb 1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Experimental Hematology. 24 (2): 310–3. PMID 8641358.

[pmid9054445-12] Mazaki Y, Hashimoto S, Sabe H (Mar 1997). "Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins". The Journal of Biological Chemistry. 272 (11): 7437–44. doi:10.1074/jbc.272.11.7437. PMID 9054445.

[pmid7534286-13] Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y, Pisick E, Hallek M, Ernst T (Mar 1995). "Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL". The Journal of Biological Chemistry. 270 (10): 5039–47. doi:10.1074/jbc.270.10.5039. PMID 7534286.

[pmid7622520-14] Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL (Jul 1995). "Interaction of focal adhesion kinase with cytoskeletal protein talin". The Journal of Biological Chemistry. 270 (28): 16995–9. doi:10.1074/jbc.270.28.16995. PMID 7622520.

[pmid9442086-15] Zheng C, Xing Z, Bian ZC, Guo C, Akbay A, Warner L, Guan JL (Jan 1998). "Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion". The Journal of Biological Chemistry. 273 (4): 2384–9. doi:10.1074/jbc.273.4.2384. PMID 9442086.

[Bass_1999-16] Bass MD, Smith BJ, Prigent SA, Critchley DR (Jul 1999). "Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix". The Biochemical Journal. 341 (2): 257–63. doi:10.1042/bj3410257. PMC 1220354. PMID 10393080.

[Gilmore_1993-17] Gilmore AP, Wood C, Ohanian V, Jackson P, Patel B, Rees DJ, Hynes RO, Critchley DR (Jul 1993). "The cytoskeletal protein talin contains at least two distinct vinculin binding domains". The Journal of Cell Biology. 122 (2): 337–47. doi:10.1083/jcb.122.2.337. PMC 2119638. PMID 8320257.

[Burridge_1984-18] Burridge K, Mangeat P (1984). "An interaction between vinculin and talin". Nature. 308 (5961): 744–6. doi:10.1038/308744a0. PMID 6425696.

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