ویکی‌پدیا

VIPR1

گیرنده ۱ پپتید وازواکتیو روده‌ای (انگلیسی: Vasoactive intestinal polypeptide receptor 1) که با نام VPAC1 هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «VIPR1» کدگذاری می‌شود.[۴] این ژن در قشر مغز، هیپوکامپ، آمیگدال، ریه، پروستات، گلبول‌های سفید، کبد، روده باریک، قلب، طحال، جفت، کلیه، تیموس و بیضه بیان می‌شود.[۵][۶][۷]

VIPR1
ساختارهای موجود
PDBجستجوی هم‌ساخت‌شناسی: PDBe RCSB
معین‌کننده‌ها
نام‌های دیگرVIPR1, HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIP-R-1, VIPR, VIRG, VPAC1, VPAC1R, VPCAP1R, vasoactive intestinal peptide receptor 1
شناسه‌های بیرونیOMIM: 192321 MGI: 109272 HomoloGene: 3399 GeneCards: VIPR1
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

7433

22354

آنسامبل

ENSG00000114812

ENSMUSG00000032528

یونی‌پروت

P32241

P97751

RefSeq (mRNA)

NM_001251882، NM_001251883، NM_001251884، NM_001251885، NM_004624، XM_005265437، XM_005265439، XM_011534080، XM_047448850، XM_047448851، XR_007095725 XR_940500، NM_001251882، NM_001251883، NM_001251884، NM_001251885، NM_004624، XM_005265437، XM_005265439، XM_011534080، XM_047448850، XM_047448851، XR_007095725

XM_006512068 NM_011703، XM_006512068

RefSeq (پروتئین)

NP_001238812، NP_001238813، NP_001238814، NP_004615، XP_005265494، XP_005265495، XP_005265496، XP_011532381، XP_011532382 NP_001238811، NP_001238812، NP_001238813، NP_001238814، NP_004615، XP_005265494، XP_005265495، XP_005265496، XP_011532381، XP_011532382

XP_006512131 NP_035833، XP_006512131

موقعیت (UCSC)ن/مChr : 121.47 – 121.5 Mb
جستجوی PubMed[۲][۳]
ویکی‌داده
مشاهده/ویرایش انسانمشاهده/ویرایش موش

اهمیت بالینی ویرایش

در مبتلایان به آشالازی با علت ناشناخته، تقاوت قابل توجهی در توزیع اس‌ان‌پی‌های مؤثر بر این پروتئین دیده می‌شود.[۸]

سطوح پپتید وازواکتیو روده‌ای و پپتید فعال‌کننده آدنیلات سیکلاز هیپوفیز در دیوارهٔ قدامی واژن در مبتلایان به «بی‌اختیاری ادراری فشاری» و «بیرون‌زدگی احشاء لگنی» کاهش یافته‌است که احتمالاً نشان‌دهندهٔ نقش آنها در پاتوفیزیولوژی این دو بیماری باشد.[۹]

منابع ویرایش

  1. ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000032528 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Entrez Gene: VIPR1 vasoactive intestinal peptide receptor 1".
  5. ↑ Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S (Apr 1992). "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide". Neuron. 8 (4): 811–9. doi:10.1016/0896-6273(92)90101-I. PMID 1314625.
  6. ↑ Usdin TB, Bonner TI, Mezey E (Dec 1994). "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions". Endocrinology. 135 (6): 2662–80. doi:10.1210/en.135.6.2662. PMID 7988457.
  7. ↑ Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ (Mar 1995). "Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene". Proceedings of the National Academy of Sciences of the United States of America. 92 (7): 2939–43. doi:10.1073/pnas.92.7.2939. PMC 42334. PMID 7708752.
  8. ↑ Paladini F, Cocco E, Cascino I, Belfiore F, Badiali D, Piretta L, Alghisi F, Anzini F, Fiorillo MT, Corazziari E, Sorrentino R (Jun 2009). "Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene". Neurogastroenterology and Motility. 21 (6): 597–602. doi:10.1111/j.1365-2982.2009.01284.x. PMID 19309439.
  9. ↑ Hong X, Huang L, Song Y (Aug 2008). "Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse". International Urogynecology Journal and Pelvic Floor Dysfunction. 19 (8): 1151–7. doi:10.1007/s00192-008-0585-z. PMID 18351280.

برای مطالعهٔ بیشتر ویرایش

  • "[Quaternary structure of rabbit skeletal muscle glycogen synthetase]" [Quaternary structure of rabbit skeletal muscle glycogen synthetase]. Doklady Akademii Nauk SSSR. 222 (4): 997–1000. Jun 1975. PMID 807467.
  • Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ (Mar 1995). "Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene". Proceedings of the National Academy of Sciences of the United States of America. 92 (7): 2939–43. doi:10.1073/pnas.92.7.2939. PMC 42334. PMID 7708752.
  • Couvineau A, Gaudin P, Maoret JJ, Rouyer-Fessard C, Nicole P, Laburthe M (Jan 1995). "Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP". Biochemical and Biophysical Research Communications. 206 (1): 246–52. doi:10.1006/bbrc.1995.1034. PMID 7818527.
  • Gagnon AW, Aiyar N, Elshourbagy NA (Mar 1994). "Molecular cloning and functional characterization of a human liver vasoactive intestinal peptide receptor". Cellular Signalling. 6 (3): 321–33. doi:10.1016/0898-6568(94)90037-X. PMID 7917790.
  • Sreedharan SP, Patel DR, Xia M, Ichikawa S, Goetzl EJ (Aug 1994). "Human vasoactive intestinal peptide1 receptors expressed by stable transfectants couple to two distinct signaling pathways". Biochemical and Biophysical Research Communications. 203 (1): 141–8. doi:10.1006/bbrc.1994.2160. PMID 8074647.
  • Couvineau A, Rouyer-Fessard C, Darmoul D, Maoret JJ, Carrero I, Ogier-Denis E, Laburthe M (Apr 1994). "Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains". Biochemical and Biophysical Research Communications. 200 (2): 769–76. doi:10.1006/bbrc.1994.1517. PMID 8179610.
  • Moody TW, Zia F, Draoui M, Brenneman DE, Fridkin M, Davidson A, Gozes I (May 1993). "A vasoactive intestinal peptide antagonist inhibits non-small cell lung cancer growth". Proceedings of the National Academy of Sciences of the United States of America. 90 (10): 4345–9. doi:10.1073/pnas.90.10.4345. PMC 46507. PMID 8389448.
  • Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (Jun 1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochemical and Biophysical Research Communications. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245.
  • Couvineau A, Fabre C, Gaudin P, Maoret JJ, Laburthe M (Feb 1996). "Mutagenesis of N-glycosylation sites in the human vasoactive intestinal peptide 1 receptor. Evidence that asparagine 58 or 69 is crucial for correct delivery of the receptor to plasma membrane". Biochemistry. 35 (6): 1745–52. doi:10.1021/bi952022h. PMID 8639654.
  • Pozo D, Guerrero JM, Segura JJ, Calvo JR (Sep 1996). "Thymosin alpha 1 interacts with the VIP receptor-effector system in rat and mouse immunocompetent cells". Immunopharmacology. 34 (2–3): 113–23. doi:10.1016/0162-3109(96)00131-2. PMID 8886855.
  • Couvineau A, Maoret JJ, Rouyer-Fessard C, Carrero I, Laburthe M (Dec 1998). "Cloning and functional characterization of the human VIP1/PACAP receptor promoter". Annals of the New York Academy of Sciences. 865: 59–63. doi:10.1111/j.1749-6632.1998.tb11163.x. PMID 9927997.
  • Knudsen SM, Tams JW, Wulff BS, Fahrenkrug J (Dec 1998). "Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production". Annals of the New York Academy of Sciences. 865: 259–65. doi:10.1111/j.1749-6632.1998.tb11186.x. PMID 9928020.
  • Marie J, Wakkach A, Coudray A, Chastre E, Berrih-Aknin S, Gespach C (Feb 1999). "Functional expression of receptors for calcitonin gene-related peptide, calcitonin, and vasoactive intestinal peptide in the human thymus and thymomas from myasthenia gravis patients". Journal of Immunology. 162 (4): 2103–12. PMID 9973484.
  • Mimuro H, Suzuki T, Suetsugu S, Miki H, Takenawa T, Sasakawa C (Sep 2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". The Journal of Biological Chemistry. 275 (37): 28893–901. doi:10.1074/jbc.M003882200. PMID 10867004.
  • Nicole P, Maoret JJ, Couvineau A, Momany FA, Laburthe M (Sep 2000). "Tryptophan 67 in the human VPAC(1) receptor: crucial role for VIP binding". Biochemical and Biophysical Research Communications. 276 (2): 654–9. doi:10.1006/bbrc.2000.3375. PMID 11027527.
  • Bajo AM, Juarranz MG, Valenzuela P, Martínez P, Prieto JC, Guijarro LG (Sep 2000). "Expression of vasoactive intestinal peptide (VIP) receptors in human uterus". Peptides. 21 (9): 1383–8. doi:10.1016/S0196-9781(00)00282-5. PMID 11072126.
  • Lara-Marquez M, O'Dorisio M, O'Dorisio T, Shah M, Karacay B (Feb 2001). "Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells". Journal of Immunology. 166 (4): 2522–30. doi:10.4049/jimmunol.166.4.2522. PMID 11160313.
  • Martin Shreeve S (Feb 2002). "Identification of G-proteins coupling to the vasoactive intestinal peptide receptor VPAC(1) using immunoaffinity chromatography: evidence for precoupling". Biochemical and Biophysical Research Communications. 290 (4): 1300–7. doi:10.1006/bbrc.2002.6342. PMID 11812005.
  • Dorsam G, Goetzl EJ (Apr 2002). "Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros". The Journal of Biological Chemistry. 277 (16): 13488–93. doi:10.1074/jbc.M107922200. PMID 11812772.
  • Branch DR, Valenta LJ, Yousefi S, Sakac D, Singla R, Bali M, Sahai BM, Ma XZ (Feb 2002). "VPAC1 is a cellular neuroendocrine receptor expressed on T cells that actively facilitates productive HIV-1 infection". AIDS. 16 (3): 309–19. doi:10.1097/00002030-200202150-00001. PMID 11834941.
برگرفته از «https://fa.wikipedia.org/w/index.php?title=VIPR1&oldid=36426638»