CD38

CD38
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4TMF, 1YH3, 1ZVM, 2EF1, 2HCT, 2I65, 2I66, 2I67, 2O3Q, 2O3R, 2O3S, 2O3T, 2O3U, 2PGJ, 2PGL, 3DZF, 3DZG, 3DZH, 3DZI, 3DZJ, 3DZK, 3F6Y, 3I9M, 3I9N, 3OFS, 3RAJ, 3ROK, 3ROM, 3ROP, 3ROQ, 3U4H, 3U4I, 4CMH, 4F45, 4F46, 4OGW, 4XJS, 4XJT, 5F1K, 5F1O, 5F21
معین‌کننده‌ها
نام‌های دیگر	CD38, ADPRC1, ADPRC 1, CD38 molecule
شناسه‌های بیرونی	OMIM: 107270 MGI: 107474 HomoloGene: 1345 GeneCards: CD38
عدد EC	2.4.99.20
موقعیت ژن (موش)
کروموزوم	کروموزوم ۵ (موش)
پایان	44,069,717 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • hydrolase activity, acting on glycosyl bonds; • NAD(P)+ nucleosidase activity; • hydrolase activity; • NAD+ nucleotidase, cyclic ADP-ribose generating; • NAD+ nucleosidase activity; • phosphorus-oxygen lyase activity; • identical protein binding;
ترکیبات سلولی	• integral component of membrane; • membrane; • intracellular membrane-bounded organelle; • cell surface; • extracellular exosome; • هسته یاخته; • پوسته یاخته; • basolateral plasma membrane; • secretory granule membrane;
فرایند زیستی	• B cell receptor signaling pathway; • response to cytokine; • response to estradiol; • response to interleukin-1; • response to hypoxia; • response to retinoic acid; • positive regulation of cytosolic calcium ion concentration; • response to progesterone; • female pregnancy; • negative regulation of apoptotic process; • response to hydroperoxide; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of cell growth; • positive regulation of B cell proliferation; • positive regulation of vasoconstriction; • long-term depression; • apoptotic signaling pathway; • response to hormone; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0072468 ورارسانی پیام; • positive regulation of insulin secretion; • negative regulation of bone resorption; • NAD metabolic process; • positive regulation of cell population proliferation; • negative regulation of neuron projection development; • artery smooth muscle contraction;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	952
	12494
	ENSG00000004468
	ENSMUSG00000029084
	P28907
	P56528
	NR_132660 NM_001775، NR_132660
	NM_007646
	NP_001766
	NP_031672
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

مجموعهٔ تمایزی ۳۸ (انگلیسی: Cluster of Differentiation 38) که با نامِ «ریبوز هیدرولاز ADP حلقوی» هم شناخته می‌شود، یک گلیکوپروتئین است^[۴] که در انسان توسط ژن «CD38» که بر روی کروموزوم ۴ قرار دارد، کُد می‌شود.^[۵]^[۶] این گلیکوپروتئین بر سطح بسیاری از گلبول‌های سفید (از جمله لنفوسیت‌های بی CD4⁺ و CD8⁺ وسلول‌های کشنده طبیعی) دیده می‌شود. این پروتئین در چسبندگی سلولی، ترارسانی پیام و ارسال سیگنال به واسطهٔ کلسیم نقش دارد.^[۷]

پروتئین CD38 در بروز اشکال در پاسخ ایمنی، اختلالات متابولیک و تغییرات رفتاری از جمله فراموشی گروهی مرتبط با اوتیسم دخیل است.^[۸]^[۹] همچنین این مولکول در عفونت اچ‌آی‌وی، سرطان‌های خون، مولتیپل میلوما، برخی تومورهای توپُر، دیابت نوع ۲، متابولیسم استخوان و برخی بیماری‌های ژنتیکی نقش دارد.

CD38 آنزیمی را می‌سازد که ترشح هورمون اکسی‌توسین از مغز را کنترل می‌کند.^[۹]

نشان داده شده که افزایش تدریجی CD38 در اثر سن، با کاهش +NAD در ارتباط است،^[۱۰]^[۱۱]

همچنین افزایش بیان ژن CD38 در لوسمی مزمن لنفاوی (CLL) با کاهش سرعت پیشرفت بیماری مرتبط است.^[۱۲]

منابع ویرایش

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000029084 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Orciani M, Trubiani O, Guarnieri S, Ferrero E, Di Primio R (October 2008). "CD38 is constitutively expressed in the nucleus of human hematopoietic cells". J. Cell. Biochem. 105 (3): 905–12. doi:10.1002/jcb.21887. PMID 18759251.
↑ Jackson DG, Bell JI (April 1990). "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation". J. Immunol. 144 (7): 2811–5. PMID 2319135.
↑ Nata K, Takamura T, Karasawa T, Kumagai T, Hashioka W, Tohgo A, Yonekura H, Takasawa S, Nakamura S, Okamoto H (February 1997). "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): 285–92. doi:10.1016/S0378-1119(96)00723-8. PMID 9074508.
↑ "Entrez Gene: CD38 CD38 molecule".
↑ Malavasi F, Deaglio S, Funaro A, Ferrero E, Horenstein AL, Ortolan E, Vaisitti T, Aydin S (July 2008). "Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology". Physiol. Rev. 88 (3): 841–86. doi:10.1152/physrev.00035.2007. PMID 18626062.
↑ ^۹٫۰ ^۹٫۱ Higashida H, Yokoyama S, Huang JJ, Liu L, Ma WJ, Akther S, Higashida C, Kikuchi M, Minabe Y, Munesue T (November 2012). "Social memory, amnesia, and autism: brain oxytocin secretion is regulated by NAD+ metabolites and single nucleotide polymorphisms of CD38". Neurochem. Int. 61 (6): 828–38. doi:10.1016/j.neuint.2012.01.030. PMID 22366648.
↑ Camacho-Pereira J, Tarragó MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN. "CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism". Cell Metab. 23 (6): 1127–1139. doi:10.1016/j.cmet.2016.05.006.
↑ Schultz M, Sinclair D. "Why NAD+ Declines during Aging: It's Destroyed". Cell Metab. 23 (6): 965–966. doi:10.1016/j.cmet.2016.05.022.
↑ Burgler S (2015). "Role of CD38 Expression in Diagnosis and Pathogenesis of Chronic Lymphocytic Leukemia and Its Potential as Therapeutic Target". Critical Reviews in Immunology. 35 (5): 417–32. doi:10.1615/CritRevImmunol.v35.i5.50. PMID 26853852.

مشارکت‌کنندگان ویکی‌پدیا. «CD38». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۹ دسامبر ۲۰۱۷.

جستارهای وابسته ویرایش

States DJ, Walseth TF, Lee HC (1993). "Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38". Trends Biochem. Sci. 17 (12): 495. doi:10.1016/0968-0004(92)90337-9. PMID 1471258.
Malavasi F, Funaro A, Roggero S, et al. (1994). "Human CD38: a glycoprotein in search of a function". Immunol. Today. 15 (3): 95–7. doi:10.1016/0167-5699(94)90148-1. PMID 8172650.
Guse AH (1999). "Cyclic ADP-ribose: a novel Ca2+-mobilising second messenger". Cell. Signal. 11 (5): 309–16. doi:10.1016/S0898-6568(99)00004-2. PMID 10376802.
Funaro A, Malavasi F (1999). "Human CD38, a surface receptor, an enzyme, an adhesion molecule and not a simple marker". J. Biol. Regul. Homeost. Agents. 13 (1): 54–61. PMID 10432444.
Mallone R, Perin PC (2006). "Anti-CD38 autoantibodies in type? diabetes". Diabetes Metab. Res. Rev. 22 (4): 284–94. doi:10.1002/dmrr.626. PMC 2763400. PMID 16544364.
Partidá-Sánchez S, Rivero-Nava L, Shi G, Lund FE (2007). "CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses". Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 590: 171–83. doi:10.1007/978-0-387-34814-8_12. ISBN 978-0-387-34813-1. PMID 17191385.
Jackson DG, Bell JI (1990). "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation". J. Immunol. 144 (7): 2811–5. PMID 2319135.
Dianzani U, Bragardo M, Buonfiglio D, et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120". Eur. J. Immunol. 25 (5): 1306–11. doi:10.1002/eji.1830250526. PMID 7539755.
Nakagawara K, Mori M, Takasawa S, et al. (1995). "Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15". Cytogenet. Cell Genet. 69 (1–2): 38–9. doi:10.1159/000133933. PMID 7835083.
Tohgo A, Takasawa S, Noguchi N, et al. (1994). "Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38". J. Biol. Chem. 269 (46): 28555–7. PMID 7961800.
Takasawa S, Tohgo A, Noguchi N, et al. (1994). "Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP". J. Biol. Chem. 268 (35): 26052–4. PMID 8253715.
Nata K, Takamura T, Karasawa T, et al. (1997). "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): 285–92. doi:10.1016/S0378-1119(96)00723-8. PMID 9074508.
Feito MJ, Bragardo M, Buonfiglio D, et al. (1997). "gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules". Int. Immunol. 9 (8): 1141–7. doi:10.1093/intimm/9.8.1141. PMID 9263011.
Ferrero E, Malavasi F (1997). "Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide+-converting enzymes: extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysian ADP-ribosyl cyclase". J. Immunol. 159 (8): 3858–65. PMID 9378973.
Deaglio S, Morra M, Mallone R, et al. (1998). "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member". J. Immunol. 160 (1): 395–402. PMID 9551996.
Yagui K, Shimada F, Mimura M, et al. (1998). "A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro". Diabetologia. 41 (9): 1024–8. doi:10.1007/s001250051026. PMID 9754820.

پیوند به بیرون ویرایش

CD38 Antigens در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم CD38 انسانی و صفحهٔ جزئیات ژنی CD38 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000029084 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_18759251-4] Orciani M, Trubiani O, Guarnieri S, Ferrero E, Di Primio R (October 2008). "CD38 is constitutively expressed in the nucleus of human hematopoietic cells". J. Cell. Biochem. 105 (3): 905–12. doi:10.1002/jcb.21887. PMID 18759251.

[pmid_2319135-5] Jackson DG, Bell JI (April 1990). "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation". J. Immunol. 144 (7): 2811–5. PMID 2319135.

[pmid_9074508-6] Nata K, Takamura T, Karasawa T, Kumagai T, Hashioka W, Tohgo A, Yonekura H, Takasawa S, Nakamura S, Okamoto H (February 1997). "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): 285–92. doi:10.1016/S0378-1119(96)00723-8. PMID 9074508.

[7] "Entrez Gene: CD38 CD38 molecule".

[pmid_18626062-8] Malavasi F, Deaglio S, Funaro A, Ferrero E, Horenstein AL, Ortolan E, Vaisitti T, Aydin S (July 2008). "Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology". Physiol. Rev. 88 (3): 841–86. doi:10.1152/physrev.00035.2007. PMID 18626062.

[Higashida_2012-9] ۹٫۰ ^۹٫۱ Higashida H, Yokoyama S, Huang JJ, Liu L, Ma WJ, Akther S, Higashida C, Kikuchi M, Minabe Y, Munesue T (November 2012). "Social memory, amnesia, and autism: brain oxytocin secretion is regulated by NAD+ metabolites and single nucleotide polymorphisms of CD38". Neurochem. Int. 61 (6): 828–38. doi:10.1016/j.neuint.2012.01.030. PMID 22366648.

[10] Camacho-Pereira J, Tarragó MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN. "CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism". Cell Metab. 23 (6): 1127–1139. doi:10.1016/j.cmet.2016.05.006.

[11] Schultz M, Sinclair D. "Why NAD+ Declines during Aging: It's Destroyed". Cell Metab. 23 (6): 965–966. doi:10.1016/j.cmet.2016.05.022.

[pmid_26853852-12] Burgler S (2015). "Role of CD38 Expression in Diagnosis and Pathogenesis of Chronic Lymphocytic Leukemia and Its Potential as Therapeutic Target". Critical Reviews in Immunology. 35 (5): 417–32. doi:10.1615/CritRevImmunol.v35.i5.50. PMID 26853852.

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